ID   SULA_EDWTE              Reviewed;         168 AA.
AC   D0ZFT0;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Cell division inhibitor SulA;
GN   Name=sulA; OrderedLocusNames=ETAE_1269;
OS   Edwardsiella tarda (strain EIB202).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=498217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EIB202;
RX   PubMed=19865481; DOI=10.1371/journal.pone.0007646;
RA   Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S.,
RA   Zhao G., Liu Q., Zhang Y.;
RT   "Genome sequence of the versatile fish pathogen Edwardsiella tarda provides
RT   insights into its adaptation to broad host ranges and intracellular
RT   niches.";
RL   PLoS ONE 4:E7646-E7646(2009).
CC   -!- FUNCTION: Component of the SOS system and an inhibitor of cell
CC       division. Accumulation of SulA causes rapid cessation of cell division
CC       and the appearance of long, non-septate filaments. In the presence of
CC       GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus
CC       inhibiting FtsZ polymerization and therefore preventing it from
CC       participating in the assembly of the Z ring. This mechanism prevents
CC       the premature segregation of damaged DNA to daughter cells during cell
CC       division (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FtsZ. {ECO:0000250}.
CC   -!- INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000250}.
CC   -!- PTM: Is rapidly cleaved and degraded by the Lon protease once DNA
CC       damage is repaired. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SulA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACY84112.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP001135; ACY84112.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; D0ZFT0; -.
DR   SMR; D0ZFT0; -.
DR   EnsemblBacteria; ACY84112; ACY84112; ETAE_1269.
DR   KEGG; etr:ETAE_1269; -.
DR   HOGENOM; CLU_118972_2_0_6; -.
DR   Proteomes; UP000002634; Chromosome.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0051782; P:negative regulation of cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004596; Cell_div_suppressor_SulA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF03846; SulA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA damage; Septation; SOS response.
FT   CHAIN           1..168
FT                   /note="Cell division inhibitor SulA"
FT                   /id="PRO_0000414244"
FT   REGION          104..110
FT                   /note="FtsZ binding"
FT                   /evidence="ECO:0000250"
FT   SITE            168
FT                   /note="Essential for degradation by Lon protease"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   168 AA;  18274 MW;  1C1228F0E7A6B7D9 CRC64;
     MRTSPLHPAT DSVVFSRPAC QSAPTVPQSG FVSELGYGAQ QPLLSLLLPP LLRQLGEQSR
     WQLWITAQHK PSKRWLSACG VPVHKVMQLR RAEAGEAIYA MEQALRSGNY SVVLGWLPPL
     TAAERLRLNR AAQAGRSIGL LMQPQEGKLA AAAPPQAHAA NRGSARYH