SULA_PSEAE
ID SULA_PSEAE Reviewed; 161 AA.
AC Q9HZJ8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Cell division inhibitor SulA;
GN Name=sulA; OrderedLocusNames=PA3008;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) UNCOMPLEXED AND IN COMPLEX WITH FTSZ,
RP AND SUBUNIT.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=12808143; DOI=10.1073/pnas.1330742100;
RA Cordell S.C., Robinson E.J., Loewe J.;
RT "Crystal structure of the SOS cell division inhibitor SulA and in complex
RT with FtsZ.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7889-7894(2003).
CC -!- FUNCTION: Component of the SOS system and an inhibitor of cell
CC division. Accumulation of SulA causes rapid cessation of cell division
CC and the appearance of long, non-septate filaments. In the presence of
CC GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus
CC inhibiting FtsZ polymerization and therefore preventing it from
CC participating in the assembly of the Z ring. This mechanism prevents
CC the premature segregation of damaged DNA to daughter cells during cell
CC division (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with FtsZ. {ECO:0000269|PubMed:12808143}.
CC -!- INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000250}.
CC -!- PTM: Is rapidly cleaved and degraded by the Lon protease once DNA
CC damage is repaired. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SulA family. {ECO:0000305}.
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DR EMBL; AE004091; AAG06396.1; -; Genomic_DNA.
DR PIR; A83269; A83269.
DR RefSeq; NP_251698.1; NC_002516.2.
DR RefSeq; WP_003091197.1; NZ_QZGE01000009.1.
DR PDB; 1OFT; X-ray; 2.90 A; A/B/C/D=1-161.
DR PDB; 1OFU; X-ray; 2.10 A; X/Y=43-161.
DR PDBsum; 1OFT; -.
DR PDBsum; 1OFU; -.
DR AlphaFoldDB; Q9HZJ8; -.
DR SMR; Q9HZJ8; -.
DR IntAct; Q9HZJ8; 1.
DR STRING; 287.DR97_4929; -.
DR PaxDb; Q9HZJ8; -.
DR DNASU; 880164; -.
DR EnsemblBacteria; AAG06396; AAG06396; PA3008.
DR GeneID; 880164; -.
DR KEGG; pae:PA3008; -.
DR PATRIC; fig|208964.12.peg.3156; -.
DR PseudoCAP; PA3008; -.
DR HOGENOM; CLU_142237_0_0_6; -.
DR OMA; SWINPLG; -.
DR PhylomeDB; Q9HZJ8; -.
DR BioCyc; PAER208964:G1FZ6-3060-MON; -.
DR EvolutionaryTrace; Q9HZJ8; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0051782; P:negative regulation of cell division; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; EXP:CollecTF.
DR DisProt; DP01948; -.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR004596; Cell_div_suppressor_SulA.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03846; SulA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; DNA damage; Reference proteome;
KW Septation; SOS response.
FT CHAIN 1..161
FT /note="Cell division inhibitor SulA"
FT /id="PRO_0000343969"
FT REGION 99..104
FT /note="FtsZ binding"
FT REGION 106..108
FT /note="FtsZ binding"
FT REGION 120..125
FT /note="FtsZ binding"
FT STRAND 45..53
FT /evidence="ECO:0007829|PDB:1OFU"
FT HELIX 55..69
FT /evidence="ECO:0007829|PDB:1OFU"
FT STRAND 73..82
FT /evidence="ECO:0007829|PDB:1OFU"
FT HELIX 89..94
FT /evidence="ECO:0007829|PDB:1OFU"
FT STRAND 101..105
FT /evidence="ECO:0007829|PDB:1OFU"
FT HELIX 110..123
FT /evidence="ECO:0007829|PDB:1OFU"
FT STRAND 126..131
FT /evidence="ECO:0007829|PDB:1OFU"
FT HELIX 138..151
FT /evidence="ECO:0007829|PDB:1OFU"
FT STRAND 154..159
FT /evidence="ECO:0007829|PDB:1OFU"
SQ SEQUENCE 161 AA; 17476 MW; 86117EB72E03BC1F CRC64;
MQTSHSLPSA QLPLFQEAFW ASNGAPLLDD VIDSPSSASI EEPAAFSELS LSGLPGHCLT
LLAPILRELS EEQDARWLTL IAPPASLTHE WLRRAGLNRE RILLLQAKDN AAALALSCEA
LRLGRSHTVV SWLEPLSRAA RKQLSRAAQL GQAQSLNIRL G
