SULA_SALTY
ID SULA_SALTY Reviewed; 169 AA.
AC P0A241; P08847;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Cell division inhibitor SulA {ECO:0000255|HAMAP-Rule:MF_01179};
GN Name=sulA {ECO:0000255|HAMAP-Rule:MF_01179}; OrderedLocusNames=STM1071;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3297925; DOI=10.1016/0378-1119(87)90392-1;
RA Freudl R., Braun G., Honore N., Cole S.T.;
RT "Evolution of the enterobacterial sulA gene: a component of the SOS system
RT encoding an inhibitor of cell division.";
RL Gene 52:31-40(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Component of the SOS system and an inhibitor of cell
CC division. Accumulation of SulA causes rapid cessation of cell division
CC and the appearance of long, non-septate filaments. In the presence of
CC GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus
CC inhibiting FtsZ polymerization and therefore preventing it from
CC participating in the assembly of the Z ring. This mechanism prevents
CC the premature segregation of damaged DNA to daughter cells during cell
CC division. {ECO:0000255|HAMAP-Rule:MF_01179}.
CC -!- SUBUNIT: Interacts with FtsZ. {ECO:0000255|HAMAP-Rule:MF_01179}.
CC -!- INDUCTION: By DNA damage, as part of the SOS response.
CC {ECO:0000255|HAMAP-Rule:MF_01179}.
CC -!- PTM: Is rapidly cleaved and degraded by the Lon protease once DNA
CC damage is repaired. {ECO:0000255|HAMAP-Rule:MF_01179}.
CC -!- SIMILARITY: Belongs to the SulA family. {ECO:0000255|HAMAP-
CC Rule:MF_01179}.
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DR EMBL; M16324; AAA27230.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20004.1; -; Genomic_DNA.
DR PIR; B29016; B29016.
DR RefSeq; NP_460045.1; NC_003197.2.
DR RefSeq; WP_000288732.1; NC_003197.2.
DR AlphaFoldDB; P0A241; -.
DR SMR; P0A241; -.
DR STRING; 99287.STM1071; -.
DR PaxDb; P0A241; -.
DR EnsemblBacteria; AAL20004; AAL20004; STM1071.
DR GeneID; 1252589; -.
DR KEGG; stm:STM1071; -.
DR PATRIC; fig|99287.12.peg.1136; -.
DR HOGENOM; CLU_118972_1_0_6; -.
DR OMA; YGFIMRP; -.
DR PhylomeDB; P0A241; -.
DR BioCyc; SENT99287:STM1071-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0051782; P:negative regulation of cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01179; SulA; 1.
DR InterPro; IPR004596; Cell_div_suppressor_SulA.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03846; SulA; 1.
DR PIRSF; PIRSF003093; SulA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00623; sula; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; DNA damage; Reference proteome; Septation;
KW SOS response.
FT CHAIN 1..169
FT /note="Cell division inhibitor SulA"
FT /id="PRO_0000072309"
FT REGION 106..112
FT /note="FtsZ binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01179"
FT REGION 162..169
FT /note="Lon protease binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01179"
FT SITE 169
FT /note="Essential for degradation by Lon protease"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01179"
FT CONFLICT 102
FT /note="S -> T (in Ref. 1; AAA27230)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="R -> A (in Ref. 1; AAA27230)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="H -> L (in Ref. 1; AAA27230)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 169 AA; 19013 MW; 3848A73595E5D176 CRC64;
MYTSGYANRS SSFPTTTHNA ARTATENAAA GLVSEVVYHE DQPMMAQLLL LPLLRQLGQQ
SRWQLWLTPQ QKLSREWVQS SGLPLTKVMQ ISQLAPRHTL ESMIRALRTG NYSVVIGWMT
EELTEEEHAS LVEAAKVGNA VGFIMRPVRA HALPRRQHSG LKIHSNLYH
