SULH1_SCHPO
ID SULH1_SCHPO Reviewed; 877 AA.
AC O74377; Q9UU11;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable sulfate permease C3H7.02;
GN ORFNames=SPBC3H7.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 428-646.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: High affinity uptake of sulfate into the cell. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA20298.1; -; Genomic_DNA.
DR EMBL; AB027878; BAA87182.1; -; Genomic_DNA.
DR PIR; T40413; T40413.
DR RefSeq; NP_595773.1; NM_001021674.2.
DR AlphaFoldDB; O74377; -.
DR SMR; O74377; -.
DR BioGRID; 277206; 4.
DR STRING; 4896.SPBC3H7.02.1; -.
DR iPTMnet; O74377; -.
DR MaxQB; O74377; -.
DR PaxDb; O74377; -.
DR PRIDE; O74377; -.
DR EnsemblFungi; SPBC3H7.02.1; SPBC3H7.02.1:pep; SPBC3H7.02.
DR GeneID; 2540681; -.
DR KEGG; spo:SPBC3H7.02; -.
DR PomBase; SPBC3H7.02; -.
DR VEuPathDB; FungiDB:SPBC3H7.02; -.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_8_0_1; -.
DR InParanoid; O74377; -.
DR OMA; EMFARNH; -.
DR PhylomeDB; O74377; -.
DR PRO; PR:O74377; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; ISS:PomBase.
DR GO; GO:1902358; P:sulfate transmembrane transport; ISS:PomBase.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..877
FT /note="Probable sulfate permease C3H7.02"
FT /id="PRO_0000080186"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 594..747
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 643..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 96374 MW; 56995A8493371E43 CRC64;
MSFIKKIKHY FADPADLPQD EAPDSVPGLV PPPSNFVPVY PEPTYSDTVS KKGTIVRVVR
HTASKLTKHG DSSQSLSTLP NNDISVGEYV EPLPSVPGWL KQNIFSHFGT RLLHYLRSLF
PIMNWLPRYN WNWLVYDFIA GITVGCVVVP QGMSYAKVAT LPAQYGLYSS FVGVAIYCIF
ATSKDVSIGP VAVMSLVTSK VIANVQAKDP NYDAAQIGTT LALLAGAITC GLGLLRLGFI
IEFIPVPAVA GFTTGSALNI MAGQVSSLMG YKSRVHTNAA TYRVIIQTLQ NLPHTKVDAA
FGLVSLFILY LVRYTCQHLI KRYTKFQRVF FLTNVLRSAV IIIVGTAISY GVCKHRRENP
PISILGTVPS GFRDMGVPVI SRKLCADLAS ELPVSVIVLL LEHISIAKSF GRVNDYKVIP
DQELIAMGAT NLIGVFFHAY PATGSFSRSA INAKSGVRTP LGGIFTAGVV VLALYCLTGA
FYYIPNAVLS AVIIHSVFDL IIPWRQTLLF WRMQPLEALI FICAVFVSVF SSIENGIYTA
VCLSAALLLF RIAKPSGSFL GILKIANKFD DDENSIDVVR DIYVPLNQKG MNPNLTVRDP
PAGVLIFRLQ ESFTYPNAGH VNSMLTSKAK TVTRRGNANI YKKASDRPWN DPAPRKKKNA
PEVEDTRPLL RAIILDFSAV NHIDTTGVQA LVDTRKELEI YAGDEVEFHF TDINNDWIKR
TLVAAGFGKA RDATKYTSRS IEVGSAAPLR DIETPMAPGN SRIVMPSSVR VRPFDEEEAI
ESSIPAIVSE DGADSDTISV SDDKDKKVEG HRPSQDPTFS HHEYYPVIST TYPFFHVDVT
SAVVDIQYRH VLDVNYKPKI VTNEVENENI EHSDGAA
