SULP3_CAEEL
ID SULP3_CAEEL Reviewed; 782 AA.
AC Q94225; Q58G77; Q58QG5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Sulfate permease family protein 3;
GN Name=sulp-3; ORFNames=F41D9.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=15814591; DOI=10.1152/ajpcell.00071.2005;
RA Sherman T., Chernova M.N., Clark J.S., Jiang L., Alper S.L., Nehrke K.;
RT "The abts and sulp families of anion transporters from Caenorhabditis
RT elegans.";
RL Am. J. Physiol. 289:C341-C351(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Possible sulfate transporter.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q94225-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q94225-2; Sequence=VSP_019780;
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; AY887909; AAX34421.1; -; mRNA.
DR EMBL; AY954524; AAX34432.2; -; mRNA.
DR EMBL; FO081091; CCD69047.1; -; Genomic_DNA.
DR PIR; T25751; T25751.
DR RefSeq; NP_509424.2; NM_077023.4. [Q94225-1]
DR AlphaFoldDB; Q94225; -.
DR SMR; Q94225; -.
DR BioGRID; 46016; 1.
DR STRING; 6239.F41D9.5; -.
DR TCDB; 2.A.53.2.20; the sulfate permease (sulp) family.
DR PaxDb; Q94225; -.
DR EnsemblMetazoa; F41D9.5.1; F41D9.5.1; WBGene00018283. [Q94225-1]
DR GeneID; 181094; -.
DR KEGG; cel:CELE_F41D9.5; -.
DR UCSC; F41D9.5; c. elegans. [Q94225-1]
DR CTD; 181094; -.
DR WormBase; F41D9.5; CE38957; WBGene00018283; sulp-3. [Q94225-1]
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; Q94225; -.
DR OMA; SKHNALG; -.
DR OrthoDB; 690428at2759; -.
DR PhylomeDB; Q94225; -.
DR Reactome; R-CEL-174362; Transport and synthesis of PAPS.
DR Reactome; R-CEL-427601; Multifunctional anion exchangers.
DR PRO; PR:Q94225; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018283; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..782
FT /note="Sulfate permease family protein 3"
FT /id="PRO_0000080193"
FT TRANSMEM 30..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 546..700
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 728..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 318..345
FT /note="VVVGITATNYAELSLRHDVKVVGNIPTE -> LTHYLINR (in isoform
FT b)"
FT /evidence="ECO:0000303|PubMed:15814591"
FT /id="VSP_019780"
SQ SEQUENCE 782 AA; 87475 MW; 36F1A26BAFF3DA3C CRC64;
MYKKMSLRQL FSDRPPLNAV LQEKAQKLRY ACSPSKCIHS LLSFLPIITW LPKYDWSHSF
FGDLSGGLTM AVFSVPQGIA LASITGVPPV YGLYTAIFPS FLYIFFGTSK HNALGGFAVL
SLMTHGAIEK VMLRTATSYN ATAYVNHTLD ELLDKENETA LISNTTLMQI LGNETSFVEE
VTMEMWTEGV TPVKQIHVAT TIIFLAGVIQ VFMGVFRLQY LTSLFSEQVM SGFVVGGGIH
VFFAQIGNML GIELPRRSGP GYLYYRIWDL VENLDNVHIP TVCISLSSFL FLVFGKEYLA
PWLNSAFNYP VPFELVLVVV GITATNYAEL SLRHDVKVVG NIPTEFPPPS LPRFDLIRHI
GLNAAAIAIT AVAIHITVAK VVEKRYKYKI NHGQELYALG FVGVLSSFFP VFPVTSGFAR
SVVGAAVGGS TQLTCLFSSL ALLSVILCIG PALEYLPQCI LSAMIIFAQK GMLEKFGELK
SLWPVFKIDF TIWLMSFFLT VCYDMGEGLL MAIGFAVLTT IIRTQRPKWH FLSRDDDTEN
YKETKKRDLE RIQGNVCIFR MDAPLIFTSS DRFTMSVWQC VKKWERCKSE SFVTIEQMNS
DRSADIFDSK LKSARRRWKR DQKSENRCKL VIDCDGFPYV DYLGLSTLKS VYVDLQAAGI
QCFFVVQKSD LKKLFRATDF YEVVDESKVF NKVGDAVKAA EQHISSPKTT KEILTALASI
ATTDTVLIDE ESSDSNDNDD AEIQERITEE SENSEEVMSE TSVSIEDATS LTSSRNSINS
EE
