SULX_YEAST
ID SULX_YEAST Reviewed; 754 AA.
AC P53394; D6W414;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Putative sulfate transporter YPR003C;
GN OrderedLocusNames=YPR003C; ORFNames=LPZ3C, YP9723.03C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Possible sulfate transporter.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
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DR EMBL; Z71255; CAA95043.1; -; Genomic_DNA.
DR EMBL; U31900; AAA97582.1; -; Genomic_DNA.
DR EMBL; Z48951; CAA88781.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11430.1; -; Genomic_DNA.
DR PIR; S52816; S52816.
DR RefSeq; NP_015328.1; NM_001184100.1.
DR AlphaFoldDB; P53394; -.
DR SMR; P53394; -.
DR BioGRID; 36180; 51.
DR DIP; DIP-5055N; -.
DR IntAct; P53394; 3.
DR MINT; P53394; -.
DR STRING; 4932.YPR003C; -.
DR TCDB; 2.A.53.1.11; the sulfate permease (sulp) family.
DR iPTMnet; P53394; -.
DR PaxDb; P53394; -.
DR PRIDE; P53394; -.
DR EnsemblFungi; YPR003C_mRNA; YPR003C; YPR003C.
DR GeneID; 856111; -.
DR KEGG; sce:YPR003C; -.
DR SGD; S000006207; YPR003C.
DR VEuPathDB; FungiDB:YPR003C; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01050000244925; -.
DR HOGENOM; CLU_003182_10_1_1; -.
DR InParanoid; P53394; -.
DR OMA; EAPHDIK; -.
DR BioCyc; YEAST:G3O-34165-MON; -.
DR Reactome; R-SCE-174362; Transport and synthesis of PAPS.
DR Reactome; R-SCE-427601; Multifunctional anion exchangers.
DR PRO; PR:P53394; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P53394; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..754
FT /note="Putative sulfate transporter YPR003C"
FT /id="PRO_0000080192"
FT TOPO_DOM 1..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..146
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..199
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..282
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..370
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 392..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..450
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..474
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 496..517
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 539..754
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 574..725
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 83384 MW; 4558DA8B79803E6E CRC64;
MTSNNSLLGR GRMSYSSTAP PRFKRSVDQR DTFSDNFDYD KDSSNRGRTY IAASNSTTGV
PPPNNSRSGC TNNTNNTNNT SNTSNTNNND SVDENTVFET LPYYLPCFSW LPEYTFNKLW
GDVIAGISVA SFQIPLALSY TTSIAHVPPL CGLYSLAISP FVYGILGSVP QMIVGPESAI
SLVVGQAVES ITLHKENVSL IDISTVITFV SGTILLFSGI SRFGFLGNVL SKALLRGFIS
SVGLVMIINS LISELKLDKF LVSLPQHYHT PFEKILFLID YAPAQYHIPT AIFSGCCLIV
LFLTRLLKRK LMKYHKSAIF FPDILLVVIV TILISMKFNL KHRYGISIIG DFSMDNFDEL
KNPLTRPRRK LIPDLFSASL IVAMLGFFES TTASKSLGTT YNLTVSSNRE LVALGFMNIV
ISLFGALPAF GGYGRSKINA LSGAQSVMSG VFMGVITLIT MNLLLQFVHY IPNCVLSVIT
TIIGISLLEE VPGDIKFHLR CGGFSELFVF AVTFCTTIFY SIEAGICIGC VYSIINIIKH
SAKSRIQILA RVAGTSNFTN LDDYMMNMKR NSLDVEGTEE IEGCMIVRIP EPLTFTNSED
LKQRLDRIER YGSSKIHPGR KSLRSKDSIK YVIFDLGGMT SIDSSAAQVL EEIITSYKRR
NVFIYLVNVS INDKVRRRLF KAGVAASVER AQANNNENNT SNTFSDAGET YSPYFDSIDA
ALYEIEKMKI KGNNVPNNDS ESFMSNTLFN SSLV
