ID   SUM1_LYTVA              Reviewed;         260 AA.
AC   Q00492;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcription factor SUM-1;
DE   AltName: Full=Sea urchin myogenic factor 1;
GN   Name=SUM-1;
OS   Lytechinus variegatus (Green sea urchin) (Echinus variegatus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7654;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2068103; DOI=10.1073/pnas.88.14.6219;
RA   Venuti J.M., Goldberg L., Chakraborty T., Olson E.N., Klein W.H.;
RT   "A myogenic factor from sea urchin embryos capable of programming muscle
RT   differentiation in mammalian cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6219-6223(1991).
CC   -!- FUNCTION: Regulatory factor during embryogenesis. Conversion of
CC       pluripotent secondary mesenchyme cells to myogenic cells. It binds to
CC       the MCK enhancer element.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Homodimer, and heterodimer with the ubiquitous bHLH protein
CC       E12.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed up from the gastrulation stage, maximal
CC       concentration during the prism stage and diminishing concentrations in
CC       the differentiating myocytes.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA30009.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M69052; AAA30009.1; ALT_INIT; mRNA.
DR   PIR; A41123; A41123.
DR   AlphaFoldDB; Q00492; -.
DR   SMR; Q00492; -.
DR   PRIDE; Q00492; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Transcription factor SUM-1"
FT                   /id="PRO_0000127453"
FT   DOMAIN          112..163
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          171..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28682 MW;  8CC5FA9D2E6DAFA4 CRC64;
     MEPMRSSCRY TEMQTVSYYE GYPSTNGDMN AYNANTAINS MYANNFPHDV HPNQARNGGH
     CYGSDSANSS PGESCREDEL EHVLAPGFHG QGERRCLMWA CKACKRKNVA VDKRKAATLR
     ERRRLRKVNE AFEALKRHTC ANPNQRLPKV EILRNAIEYI EKLERLLQVE KANGDSEMDS
     AETSSNTSDA MTDGSSPGSY SSDKAQQYGD GYDVSSPYGY NCGNASSLDC LSLIVESITP
     NKGKAITSPK KATSDGLCMV