SUM2_SCHPO
ID SUM2_SCHPO Reviewed; 426 AA.
AC Q9HGL3; P78821;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein sum2;
GN Name=sum2; ORFNames=SPBC800.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for G2/M phase checkpoint control.
CC -!- INTERACTION:
CC Q9HGL3; O13828: dcp2; NbExp=4; IntAct=EBI-1117052, EBI-3647323;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13831.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D89169; BAA13831.1; ALT_FRAME; mRNA.
DR EMBL; CU329671; CAC01524.1; -; Genomic_DNA.
DR PIR; T42532; T42532.
DR RefSeq; NP_595110.1; NM_001021017.2.
DR AlphaFoldDB; Q9HGL3; -.
DR SMR; Q9HGL3; -.
DR BioGRID; 277347; 184.
DR IntAct; Q9HGL3; 2.
DR MINT; Q9HGL3; -.
DR STRING; 4896.SPBC800.09.1; -.
DR iPTMnet; Q9HGL3; -.
DR MaxQB; Q9HGL3; -.
DR PaxDb; Q9HGL3; -.
DR PRIDE; Q9HGL3; -.
DR EnsemblFungi; SPBC800.09.1; SPBC800.09.1:pep; SPBC800.09.
DR GeneID; 2540829; -.
DR KEGG; spo:SPBC800.09; -.
DR PomBase; SPBC800.09; sum2.
DR VEuPathDB; FungiDB:SPBC800.09; -.
DR eggNOG; KOG1073; Eukaryota.
DR HOGENOM; CLU_019221_4_1_1; -.
DR InParanoid; Q9HGL3; -.
DR OMA; HPRWSPY; -.
DR PRO; PR:Q9HGL3; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0030371; F:translation repressor activity; ISO:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:1904689; P:negative regulation of cytoplasmic translational initiation; ISO:PomBase.
DR GO; GO:0033962; P:P-body assembly; ISO:PomBase.
DR GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR CDD; cd01736; LSm14_N; 1.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR025761; FFD_box.
DR InterPro; IPR025609; Lsm14-like_N.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR025768; TFG_box.
DR Pfam; PF12701; LSM14; 1.
DR SMART; SM01199; FDF; 1.
DR SMART; SM01271; LSM14; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS51513; FFD; 1.
DR PROSITE; PS51536; TFG; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Reference proteome.
FT CHAIN 1..426
FT /note="Protein sum2"
FT /id="PRO_0000072312"
FT DOMAIN 296..332
FT /note="DFDF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00845"
FT REGION 79..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 335..351
FT /note="FFD box"
FT MOTIF 360..380
FT /note="TFG box"
FT COMPBIAS 226..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 34
FT /note="A -> V (in Ref. 1; BAA13831)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="F -> L (in Ref. 1; BAA13831)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="Y -> H (in Ref. 1; BAA13831)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 46225 MW; 3E97B4263D2FAF4D CRC64;
MTEFIGSRIS LISKSDIRYV GILQDINSQD STLALKHVRW CGTEGRKQDP SQEIPPSDNV
FDYIVFRGSD VKDLRIEEPA TTPSAPPVQP PNDPAIIGSN SGQYNWNQAQ TAQPPQPVQP
NPYGAPYQQA PPAGAPYYMY PNAPAQFVPP GGLPLGTPLD ASTPAVPYYG APDQQQMGQR
PEFAQNVSQG FAGQAPYNVR PGYGMPSNQK PPNFAPGMPA PGPTAVSASP SLQSMPPTNG
VIPGAQPSIE ASIEKESTSI RNSTVTNDRV VNTTVDVSQS QTVETSGPSK EVPTTQPDAS
AAKPRTEFDF QTANQKFQSM KDDLLKGKND EEAEEFYKPK QSFFDNISCE SKEKGMEAAD
RRALRDRERS LNMETFGVAG SGNRGRRGRG RGRGGRGRGR GYARNQYNQY RNSNGSQPRA
QPANDQ
