位置:首页 > 蛋白库 > SUMO2_DANRE
SUMO2_DANRE
ID   SUMO2_DANRE             Reviewed;          96 AA.
AC   Q6DHL4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Small ubiquitin-related modifier 2 {ECO:0000305};
DE            Short=SUMO-2 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=sumo2 {ECO:0000305}; ORFNames=zgc:92241 {ECO:0000312|EMBL:AAH75956.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ubiquitin-like protein that can be covalently attached to
CC       proteins as a monomer or as a lysine-linked polymer. Covalent
CC       attachment via an isopeptide bond to its substrates requires prior
CC       activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme
CC       ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-
CC       translational modification on lysine residues of proteins plays a
CC       crucial role in a number of cellular processes such as nuclear
CC       transport, DNA replication and repair, mitosis and signal transduction.
CC       Polymeric sumo2 chains are also susceptible to polyubiquitination which
CC       functions as a signal for proteasomal degradation of modified proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with sae2 and ube2i. Covalently attached to a number
CC       of proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Polymeric chains can be formed through Lys-11 cross-linking.
CC       {ECO:0000250}.
CC   -!- PTM: Cleavage of precursor form by a sentrin-specific protease is
CC       necessary for function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin family. SUMO subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC075956; AAH75956.1; -; mRNA.
DR   RefSeq; NP_001003422.1; NM_001003422.2.
DR   AlphaFoldDB; Q6DHL4; -.
DR   SMR; Q6DHL4; -.
DR   STRING; 7955.ENSDARP00000066628; -.
DR   PaxDb; Q6DHL4; -.
DR   PeptideAtlas; Q6DHL4; -.
DR   Ensembl; ENSDART00000157771; ENSDARP00000137571; ENSDARG00000102741.
DR   Ensembl; ENSDART00000166758; ENSDARP00000131145; ENSDARG00000102741.
DR   GeneID; 445027; -.
DR   KEGG; dre:445027; -.
DR   CTD; 445027; -.
DR   ZFIN; ZDB-GENE-040801-7; sumo2b.
DR   eggNOG; KOG1769; Eukaryota.
DR   GeneTree; ENSGT00950000182895; -.
DR   HOGENOM; CLU_148322_2_1_1; -.
DR   InParanoid; Q6DHL4; -.
DR   OMA; AYCDRVG; -.
DR   OrthoDB; 1583700at2759; -.
DR   PhylomeDB; Q6DHL4; -.
DR   Reactome; R-DRE-196791; Vitamin D (calciferol) metabolism.
DR   Reactome; R-DRE-3065679; SUMO is proteolytically processed.
DR   Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-DRE-3232118; SUMOylation of transcription factors.
DR   Reactome; R-DRE-3899300; SUMOylation of transcription cofactors.
DR   Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-DRE-4090294; SUMOylation of intracellular receptors.
DR   Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-DRE-5693607; Processing of DNA double-strand break ends.
DR   Reactome; R-DRE-5696395; Formation of Incision Complex in GG-NER.
DR   PRO; PR:Q6DHL4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000102741; Expressed in pharyngeal gill and 31 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR   GO; GO:0044389; F:ubiquitin-like protein ligase binding; IBA:GO_Central.
DR   GO; GO:0043009; P:chordate embryonic development; IGI:ZFIN.
DR   GO; GO:0060216; P:definitive hemopoiesis; IGI:ZFIN.
DR   GO; GO:0016925; P:protein sumoylation; IBA:GO_Central.
DR   InterPro; IPR022617; Rad60/SUMO-like_dom.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF11976; Rad60-SLD; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..93
FT                   /note="Small ubiquitin-related modifier 2"
FT                   /id="PRO_0000269469"
FT   PROPEP          94..96
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000269470"
FT   DOMAIN          16..96
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   CROSSLNK        11
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        93
FT                   /note="Glycyl lysine isopeptide (Gly-Lys) (interchain with
FT                   K-? in acceptor proteins)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ   SEQUENCE   96 AA;  11029 MW;  B797B5D4B322BEF0 CRC64;
     MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLTMRQIRF
     RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGHRI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024