SUMO3_XENTR
ID SUMO3_XENTR Reviewed; 94 AA.
AC Q6DK72;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Small ubiquitin-related modifier 3;
DE Short=SUMO-3;
DE Flags: Precursor;
GN Name=sumo3; ORFNames=TEgg028f07.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ubiquitin-like protein which can be covalently attached to
CC target lysines either as a monomer or as a lysine-linked polymer. Does
CC not seem to be involved in protein degradation and may function as an
CC antagonist of ubiquitin in the degradation process. Plays a role in a
CC number of cellular processes such as nuclear transport, DNA replication
CC and repair, mitosis and signal transduction. Covalent attachment to its
CC substrates requires prior activation by the E1 complex sae1-sae2 and
CC linkage to the E2 enzyme ube2i (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with sae2 and ube2i. Covalently attached to a number
CC of proteins (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, PML body
CC {ECO:0000250}.
CC -!- PTM: Polymeric chains can be formed through Lys-11 cross-linking.
CC {ECO:0000250}.
CC -!- PTM: Cleavage of precursor form by a sentrin-specific protease is
CC necessary for function. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin family. SUMO subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR761360; CAJ81372.1; -; mRNA.
DR EMBL; BC074674; AAH74674.1; -; mRNA.
DR RefSeq; NP_001004853.1; NM_001004853.1.
DR AlphaFoldDB; Q6DK72; -.
DR SMR; Q6DK72; -.
DR PaxDb; Q6DK72; -.
DR DNASU; 100125978; -.
DR Ensembl; ENSXETT00000062462; ENSXETP00000059772; ENSXETG00000027487.
DR GeneID; 100125978; -.
DR KEGG; xtr:100125978; -.
DR CTD; 6612; -.
DR Xenbase; XB-GENE-1004211; sumo3.
DR HOGENOM; CLU_148322_2_1_1; -.
DR InParanoid; Q6DK72; -.
DR OrthoDB; 1583700at2759; -.
DR PhylomeDB; Q6DK72; -.
DR Reactome; R-XTR-3065679; SUMO is proteolytically processed.
DR Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-XTR-3232118; SUMOylation of transcription factors.
DR Reactome; R-XTR-3899300; SUMOylation of transcription cofactors.
DR Reactome; R-XTR-4090294; SUMOylation of intracellular receptors.
DR Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-XTR-4755510; SUMOylation of immune response proteins.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027487; Expressed in egg cell and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR GO; GO:0044389; F:ubiquitin-like protein ligase binding; IBA:GO_Central.
DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central.
DR InterPro; IPR022617; Rad60/SUMO-like_dom.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF11976; Rad60-SLD; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation;
KW Ubl conjugation pathway.
FT CHAIN 1..92
FT /note="Small ubiquitin-related modifier 3"
FT /id="PRO_0000267636"
FT PROPEP 93..94
FT /evidence="ECO:0000250"
FT /id="PRO_0000267637"
FT DOMAIN 15..92
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT CROSSLNK 11
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO)"
FT /evidence="ECO:0000250"
FT CROSSLNK 92
FT /note="Glycyl lysine isopeptide (Gly-Lys) (interchain with
FT K-? in acceptor proteins)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
SQ SEQUENCE 94 AA; 10713 MW; B315887FB123B46F CRC64;
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCDRQ GLSMRQIRFR
FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVC
