SUMV1_CAEEL
ID SUMV1_CAEEL Reviewed; 1024 AA.
AC P46582;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein sumv-1 {ECO:0000305};
DE AltName: Full=Suppressor of synthetic multivulva protein 1 {ECO:0000312|WormBase:C34E10.8};
GN Name=sumv-1 {ECO:0000312|WormBase:C34E10.8};
GN ORFNames=C34E10.8 {ECO:0000312|WormBase:C34E10.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=24882710; DOI=10.1016/j.ydbio.2014.05.018;
RA Yucel D., Hoe M., Llamosas E., Kant S., Jamieson C., Young P.A.,
RA Crossley M., Nicholas H.R.;
RT "SUMV-1 antagonizes the activity of synthetic multivulva genes in
RT Caenorhabditis elegans.";
RL Dev. Biol. 392:266-282(2014).
CC -!- FUNCTION: Nuclear factor that influences the activity of genes involved
CC in vulval development. {ECO:0000269|PubMed:24882710}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24882710}. Cytoplasm
CC {ECO:0000269|PubMed:24882710}. Cell projection, axon
CC {ECO:0000269|PubMed:24882710}. Note=Expression is restricted to the
CC nucleus in most cells, but it is also expressed in the cytoplasm and
CC neuronal projections in neurons. {ECO:0000269|PubMed:24882710}.
CC -!- DEVELOPMENTAL STAGE: Broadly expressed in neuronal, intestinal and in
CC hypodermal cells, including hyp7 cells, throughout the larval stages
CC and persisting into adulthood. {ECO:0000269|PubMed:24882710}.
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DR EMBL; FO080774; CCD66652.1; -; Genomic_DNA.
DR PIR; T15765; T15765.
DR RefSeq; NP_498116.2; NM_065715.4.
DR AlphaFoldDB; P46582; -.
DR SMR; P46582; -.
DR BioGRID; 40951; 5.
DR IntAct; P46582; 4.
DR MINT; P46582; -.
DR STRING; 6239.C34E10.8; -.
DR iPTMnet; P46582; -.
DR World-2DPAGE; 0011:P46582; -.
DR EPD; P46582; -.
DR PaxDb; P46582; -.
DR PeptideAtlas; P46582; -.
DR EnsemblMetazoa; C34E10.8.1; C34E10.8.1; WBGene00016409.
DR GeneID; 175720; -.
DR KEGG; cel:CELE_C34E10.8; -.
DR UCSC; C34E10.8; c. elegans.
DR CTD; 175720; -.
DR WormBase; C34E10.8; CE32158; WBGene00016409; sumv-1.
DR eggNOG; ENOG502TFSI; Eukaryota.
DR GeneTree; ENSGT00940000157974; -.
DR HOGENOM; CLU_011386_0_0_1; -.
DR InParanoid; P46582; -.
DR OMA; IYGECEY; -.
DR OrthoDB; 989598at2759; -.
DR SignaLink; P46582; -.
DR PRO; PR:P46582; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016409; Expressed in embryo and 4 other tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0043005; C:neuron projection; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR InterPro; IPR025927; Potential_DNA-bd.
DR Pfam; PF13891; zf-C3Hc3H; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Developmental protein; Nucleus;
KW Reference proteome.
FT CHAIN 1..1024
FT /note="Protein sumv-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000065224"
FT REGION 447..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1024
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 112207 MW; AC75AFB9370A757E CRC64;
MKQTTRPPAQ YIVAPGTRFR LVANEYDKNK YGQCNYASYR TLVRCKQIRS KEELAKHGGR
CEEHVEFSKT LENNHKKEVM RCHAENDSKM QRRRFDPWIA SNEYISDDDD YLQAAQTVPQ
RLPDVANDDI LDNNSLRYAE YYTDKDILNI KMDLVQKDID DLIEFKELVT SQAQKEHELL
GNDEEEDYPT DMAQRRIFKA STKYSRNDYL TLTTIDPVFH QCCVGPDMDD SLVIVHTMHS
ILDKIDNFEP IDSEKQCNKP ALHLSKFCFD HIILDRSQKM FDVCNACGLT AIGGVDPKCS
FHIKSSAIAE TTSCPCNRCV QPGEHASPKD EKNSITCYLN SSDDDEPTLG NLSRIESMVS
PMQQFSNQSN TLTAPLPRRY QGPPAQVLRP PQMGPPPGIN QVPYQPKANR TPPMTSQQLH
EQQKLKMQEE EMMSQTCASD FRVRPIDASQ FGGGKKKQRL PPRRSPSFGT SPNSYQFHQQ
SQKKMPSIIS TAYNSSPGKM NFQGWKNQST SSATRPLPQP RFPVHAARSQ QPKMIPLEQT
QDSIEDDIGP SPMFQGPEPS RRGVPYYKNA YRRTELPSRH AQHSPLTPST STSSSQLLAP
PKSPQPGTSS QTFRSQASRL PIAPHRAIAA GLNPADVGTR PAYRSQMAGQ RPGMTPSAQQ
GSPQLISPPR QGSMMPVAMN QSPQAVRRQT PVPPYRLMGP QRVTTSYTVV RSGSSSSVAG
PSRSSVASGS QHTALDTVQH DPRLANINVR TFLSIGNRDL STLTQDEIDL LMAGNSPEKG
GRKAGAPGAK ESSKAAGGAQ KGTSAASTSV PEPTKSSESS VDPQSDVSFS NPSPAPEVIE
KVAPAAMTIT SNKRKIDETL ASESTSSEAT LIHDTTSSSS AETVSGEPPA KKSSDVSAPV
PSPEKEKEKI DRPKTPKSST KRTTPTPSGR TPRAAAIAAN QAISHSKPNV PSASTSSSAA
STDQENPLDL LAELSVAAAA EEQQQAIGST SKNGGSTKKT QRKSPSRSSI GKKRENSEEY
EEEL
