SUN1_DICDI
ID SUN1_DICDI Reviewed; 905 AA.
AC Q558Z2;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Sun domain-containing protein 1;
GN Name=sun1; ORFNames=DDB_G0272869;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, AND SUBUNIT.
RX PubMed=18266910; DOI=10.1111/j.1600-0854.2008.00721.x;
RA Xiong H., Rivero F., Euteneuer U., Mondal S., Mana-Capelli S.,
RA Larochelle D., Vogel A., Gassen B., Noegel A.A.;
RT "Dictyostelium Sun-1 connects the centrosome to chromatin and ensures
RT genome stability.";
RL Traffic 9:708-724(2008).
RN [4]
RP SUBCELLULAR LOCATION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19632001; DOI=10.1016/j.ejcb.2009.06.003;
RA Schulz I., Baumann O., Samereier M., Zoglmeier C., Graef R.;
RT "Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes
RT and required for centrosomal association with clustered centromeres.";
RL Eur. J. Cell Biol. 88:621-638(2009).
CC -!- FUNCTION: May have an important role in defining the spacing of the
CC nuclear envelope lumen. Essential for centrosome attachment to the
CC nucleus, maintenance of correct ploidy, proper mitosis, association of
CC the centromere cluster with the centrosome and the maintenance of
CC genome stability. Requires direct chromatin binding for inner nuclear
CC membrane targeting. {ECO:0000269|PubMed:18266910,
CC ECO:0000269|PubMed:19632001}.
CC -!- SUBUNIT: Homodimer and homooligomer. {ECO:0000269|PubMed:18266910}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:18266910,
CC ECO:0000269|PubMed:19632001}; Single-pass membrane protein
CC {ECO:0000269|PubMed:18266910, ECO:0000269|PubMed:19632001};
CC Nucleoplasmic side {ECO:0000269|PubMed:18266910,
CC ECO:0000269|PubMed:19632001}.
CC -!- DISRUPTION PHENOTYPE: Shows significant reduced growth.
CC {ECO:0000269|PubMed:19632001}.
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DR EMBL; AAFI02000008; EAL71072.1; -; Genomic_DNA.
DR RefSeq; XP_644924.1; XM_639832.1.
DR AlphaFoldDB; Q558Z2; -.
DR SMR; Q558Z2; -.
DR STRING; 44689.DDB0219949; -.
DR TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR PaxDb; Q558Z2; -.
DR PRIDE; Q558Z2; -.
DR EnsemblProtists; EAL71072; EAL71072; DDB_G0272869.
DR GeneID; 8618603; -.
DR KEGG; ddi:DDB_G0272869; -.
DR dictyBase; DDB_G0272869; sun1.
DR eggNOG; KOG2687; Eukaryota.
DR HOGENOM; CLU_320658_0_0_1; -.
DR InParanoid; Q558Z2; -.
DR OMA; NISHHID; -.
DR PRO; PR:Q558Z2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005639; C:integral component of nuclear inner membrane; IEA:InterPro.
DR GO; GO:0005635; C:nuclear envelope; IDA:dictyBase.
DR GO; GO:0005637; C:nuclear inner membrane; IDA:dictyBase.
DR GO; GO:0005640; C:nuclear outer membrane; IDA:dictyBase.
DR GO; GO:0005654; C:nucleoplasm; IDA:dictyBase.
DR GO; GO:0003682; F:chromatin binding; IDA:dictyBase.
DR GO; GO:0003677; F:DNA binding; IDA:dictyBase.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034508; P:centromere complex assembly; IMP:dictyBase.
DR GO; GO:0007098; P:centrosome cycle; IMP:dictyBase.
DR GO; GO:0051642; P:centrosome localization; IMP:dictyBase.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:dictyBase.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0006997; P:nucleus organization; IMP:dictyBase.
DR InterPro; IPR045119; SUN1-5.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12911; PTHR12911; 2.
DR Pfam; PF07738; Sad1_UNC; 1.
DR PROSITE; PS51469; SUN; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Membrane; Mitosis; Nucleus;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..905
FT /note="Sun domain-containing protein 1"
FT /id="PRO_0000390618"
FT TOPO_DOM 1..290
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..905
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT DOMAIN 662..860
FT /note="SUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..221
FT /evidence="ECO:0000255"
FT COILED 359..456
FT /evidence="ECO:0000255"
FT COILED 504..609
FT /evidence="ECO:0000255"
FT COILED 864..901
FT /evidence="ECO:0000255"
FT COMPBIAS 41..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 104743 MW; 208FA7368F3280D2 CRC64;
MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN NSNNHLLHNS
NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS SYSINNKVDH NSHNNNDDDD
IEDDVDINYS TNNASSNILH NRFSNSNKDD SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID
NNSNKNIISK FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL
FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL YPIIDEYFKK
NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL VKLSNMDEDR VNQLISKMIN
HYNNNENNKQ ELKELLSKSI EELTKLKSDS KEQLIQISTE SMNQLGQLKS ESINQLGQVK
SESIDKFQST LKSLSKEEQS KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ
SSLLKLTQEY KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN
QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK IAKVDYALGL
AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL YYYNLATNWI FPQPKPNPPE
TILDPMVNTG SCWGFYTGNG TIVIRLAKKI AITEVTMEHI SSNISHHIDS APKEFQVFGL
INSSDIGQSL GVFTYDTTIN RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL
SNHGYRYTCI YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ
QSDEL
