ID   SUN3_BOVIN              Reviewed;         360 AA.
AC   Q0II64;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=SUN domain-containing protein 3;
DE   AltName: Full=Sad1/unc-84 domain-containing protein 1;
GN   Name=SUN3; Synonyms=SUNC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a probable component of the LINC (LInker of Nucleoskeleton
CC       and Cytoskeleton) complex, involved in the connection between the
CC       nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions
CC       established by the LINC complex play an important role in the
CC       transmission of mechanical forces across the nuclear envelope and in
CC       nuclear movement and positioning. May be involved in nuclear remodeling
CC       during sperm head formation in spermatogenesis. A probable SUN3:SYNE1
CC       LINC complex may tether spermatid nuclei to posterior cytoskeletal
CC       structures such as the manchette. {ECO:0000250|UniProtKB:Q5SS91}.
CC   -!- SUBUNIT: Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed
CC       to form a spermatogenesis-specific LINC complex with SYNE1 during sperm
CC       head formation possibly implicating a SUN domain-based heterotrimer
CC       with SPAG4/SUN4 associating with SYNE1. {ECO:0000250|UniProtKB:Q5SS91}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:Q5SS91}.
CC       Nucleus inner membrane {ECO:0000305}.
CC   -!- DOMAIN: The short coiled coil domain is proposed to be not involved in
CC       load-bearing and force transmission from the cytoskeleton but in mere
CC       nucleus anchorage instead. {ECO:0000250|UniProtKB:Q8TAQ9}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI22786.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC122785; AAI22786.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001069552.2; NM_001076084.2.
DR   AlphaFoldDB; Q0II64; -.
DR   SMR; Q0II64; -.
DR   STRING; 9913.ENSBTAP00000010721; -.
DR   PaxDb; Q0II64; -.
DR   PRIDE; Q0II64; -.
DR   GeneID; 537130; -.
DR   KEGG; bta:537130; -.
DR   CTD; 256979; -.
DR   eggNOG; KOG2687; Eukaryota.
DR   InParanoid; Q0II64; -.
DR   OrthoDB; 1569602at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005639; C:integral component of nuclear inner membrane; IEA:InterPro.
DR   InterPro; IPR045119; SUN1-5.
DR   InterPro; IPR030274; SUN3.
DR   InterPro; IPR012919; SUN_dom.
DR   PANTHER; PTHR12911; PTHR12911; 1.
DR   PANTHER; PTHR12911:SF24; PTHR12911:SF24; 1.
DR   Pfam; PF07738; Sad1_UNC; 1.
DR   PROSITE; PS51469; SUN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..360
FT                   /note="SUN domain-containing protein 3"
FT                   /id="PRO_0000312219"
FT   TOPO_DOM        1..47
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        48..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..360
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          196..357
FT                   /note="SUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          103..142
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   360 AA;  40619 MW;  BC79CF7E40FAA8E3 CRC64;
     MSGRPNSRGS SRLFRAPSED ASSGSSGSAV LPQEENPNAS GLTRSWKAVM GMVFILTLLL
     LGFINHMKLK EKAFPQKSRQ IYAVIAEYGS RLYNYQARLR MPKEQLELLK KESQTLENNF
     REILFLIEQI DVLKALLRDM QDGLHNYSWN ADIDPAEGWN HTEVIDEEMS NLVNYILKKL
     REDQVQMADY ALKSAGASVV EAGTSESYKN NKAKLYWHGI GFLNYEMPPD IILQPDVHPG
     KCWAFPGSQG HALIKLARKI IPTAVTMEHI SEKVSPSGNI SSAPKEFSVY GVLKQCEGEE
     IFLGQFVYNK TGTTVQTFAL QHEVPEFLLC VKLKILSNWG HPNYTCLYRF RVHGTPKDDS