SUN3_MACFA
ID SUN3_MACFA Reviewed; 361 AA.
AC Q95LV7; G7P1S8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-JAN-2017, sequence version 2.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=SUN domain-containing protein 3;
DE AltName: Full=Sad1/unc-84 domain-containing protein 1;
GN Name=SUN3; Synonyms=SUNC1; ORFNames=QtsA-17495;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-361 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- FUNCTION: As a probable component of the LINC (LInker of Nucleoskeleton
CC and Cytoskeleton) complex, involved in the connection between the
CC nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions
CC established by the LINC complex play an important role in the
CC transmission of mechanical forces across the nuclear envelope and in
CC nuclear movement and positioning. May be involved in nuclear remodeling
CC during sperm head formation in spermatogenesis. A probable SUN3:SYNE1
CC LINC complex may tether spermatid nuclei to posterior cytoskeletal
CC structures such as the manchette. {ECO:0000250|UniProtKB:Q5SS91}.
CC -!- SUBUNIT: Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed
CC to form a spermatogenesis-specific LINC complex with SYNE1 during sperm
CC head formation possibly implicating a SUN domain-based heterotrimer
CC with SPAG4/SUN4 associating with SYNE1. {ECO:0000250|UniProtKB:Q5SS91}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:Q5SS91}.
CC Nucleus inner membrane {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95LV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95LV7-2; Sequence=VSP_058700;
CC -!- DOMAIN: The short coiled coil domain is proposed to be not involved in
CC load-bearing and force transmission from the cytoskeleton but in mere
CC nucleus anchorage instead. {ECO:0000250|UniProtKB:Q8TAQ9}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB64478.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CM001278; EHH52136.1; -; Genomic_DNA.
DR EMBL; AB071084; BAB64478.1; ALT_INIT; mRNA.
DR RefSeq; XP_005549683.1; XM_005549626.2. [Q95LV7-2]
DR AlphaFoldDB; Q95LV7; -.
DR SMR; Q95LV7; -.
DR STRING; 9541.XP_005549682.1; -.
DR Ensembl; ENSMFAT00000066970; ENSMFAP00000016438; ENSMFAG00000031387. [Q95LV7-1]
DR GeneID; 102136181; -.
DR KEGG; mcf:102136181; -.
DR CTD; 256979; -.
DR VEuPathDB; HostDB:ENSMFAG00000031387; -.
DR eggNOG; KOG2687; Eukaryota.
DR GeneTree; ENSGT00940000161393; -.
DR OMA; QGHILIR; -.
DR OrthoDB; 1569602at2759; -.
DR Proteomes; UP000009130; Chromosome 3.
DR Proteomes; UP000233100; Chromosome 3.
DR Bgee; ENSMFAG00000031387; Expressed in multicellular organism.
DR GO; GO:0005639; C:integral component of nuclear inner membrane; IEA:InterPro.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR InterPro; IPR045119; SUN1-5.
DR InterPro; IPR030274; SUN3.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12911; PTHR12911; 1.
DR PANTHER; PTHR12911:SF24; PTHR12911:SF24; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR PROSITE; PS51469; SUN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..361
FT /note="SUN domain-containing protein 3"
FT /id="PRO_0000312221"
FT TOPO_DOM 1..47
FT /note="Nuclear"
FT /evidence="ECO:0000305"
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..361
FT /note="Perinuclear space"
FT /evidence="ECO:0000305"
FT DOMAIN 197..358
FT /note="SUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..129
FT /evidence="ECO:0000255"
FT VAR_SEQ 164..167
FT /note="Missing (in isoform 2)"
FT /id="VSP_058700"
SQ SEQUENCE 361 AA; 40839 MW; 374EC9EEDEE48995 CRC64;
MSGKAKARRA AMFFRGCSED ASGSTSGSTL LSEDENPDTN GVTRSWKIIL STMFTLTFLL
VGLLSHQWLK ETEVPQKSRQ LYAIIAEYGS RLYKYQARLR MPKEQLELLK KESQTLENNF
HKILLLIEQI DVLKALLRDM KDGTDNNHSW NTHGDPVEDP DHTEVLDEEM SNLVNYVLKK
LREDQVQMAD YALKSAGASI IEAGTSESYK NNKAKLYWHG ISFLNHEMPP DIILQPDVYP
GNCWAFPGSQ GHTLIKLATK IIPTAVTMEH ISEKVSPSGN ISSAPKEFSV YGITKKCEGE
EIFLGQFIYN KTGTTVQTFE LQHAVSEYLL CVKLNIFSNW GHPKYTCLYR FRVHGTPGKH
I
