ID   SUN41_ARTBC             Reviewed;         449 AA.
AC   D4AM57;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Probable secreted beta-glucosidase ARB_04747 {ECO:0000305};
DE            EC=3.2.1.- {ECO:0000250|UniProtKB:Q59NP5};
DE   Flags: Precursor;
GN   ORFNames=ARB_04747;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=21919205; DOI=10.1002/pmic.201100234;
RA   Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B.,
RA   Staib P., Neuhaus J.M., Quadroni M., Monod M.;
RT   "Identification of novel secreted proteases during extracellular
RT   proteolysis by dermatophytes at acidic pH.";
RL   Proteomics 11:4422-4433(2011).
CC   -!- FUNCTION: Cell surface beta-glucosidase involved in cytokinesis, cell
CC       wall biogenesis, adhesion to host tissue; thus playing an important
CC       role in the host-pathogen interaction. Has hydrolytic activity on
CC       linear (1->3)-beta-D-glucans such as laminaribiose and other
CC       laminarioligosaccharides. {ECO:0000250|UniProtKB:Q59NP5}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000250|UniProtKB:Q59NP5}. Secreted {ECO:0000269|PubMed:21919205}.
CC   -!- SIMILARITY: Belongs to the SUN family. {ECO:0000305}.
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DR   EMBL; ABSU01000002; EFE35813.1; -; Genomic_DNA.
DR   RefSeq; XP_003016458.1; XM_003016412.1.
DR   AlphaFoldDB; D4AM57; -.
DR   STRING; 663331.D4AM57; -.
DR   EnsemblFungi; EFE35813; EFE35813; ARB_04747.
DR   GeneID; 9521940; -.
DR   KEGG; abe:ARB_04747; -.
DR   eggNOG; ENOG502QPVV; Eukaryota.
DR   HOGENOM; CLU_033459_1_0_1; -.
DR   OMA; CSYACQS; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005556; SUN.
DR   Pfam; PF03856; SUN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Cell wall; Cell wall biogenesis/degradation;
KW   Glycoprotein; Glycosidase; Hydrolase; Polysaccharide degradation;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..449
FT                   /note="Probable secreted beta-glucosidase ARB_04747"
FT                   /id="PRO_5003054116"
FT   REGION          96..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..127
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   449 AA;  47606 MW;  00AAFF1864F21426 CRC64;
     MKFSSGILSL AVAASVQSVQ ASYHAHGHAH HHRVLNKRAD PDVVTIPGPK VYAFILNGSE
     MSKEQVCAGI RDGRLDWSGQ NHDELCGFPV GMQKGSPPAC PAPSYVPSPP AAPSSPPAAP
     QPPSKSPETP EEPKKPEEPK KPEGPKKPEG PKTPSPKKPD GPQHPQTPTG GEGVNRPFPD
     GEIDCGDFPS KYGAVPVDYL GLGGYTGIQH TTLVGEVFGT IRTAIAGESC TDGAMCSYAC
     PPGYQKSQWP EQQGSTGESV GGLACRNGKL YLTNRKLSTR LCISGVGGVH IKSTISVEIS
     ICRTDYPGTE SETVPVPLPP HGHLPLTCPQ AETYYFWQGK STSAQYYVNP PGYGPAKACQ
     WGHAGLPIGN WAPVNIGVGE KGGVKWLSMF PNRPTTTAIL HMTIEIVGEG LSGKCKHKDG
     KYYTDTGVNE DGCTVSVLHG EATFVFSYD