SUN5_ARATH
ID SUN5_ARATH Reviewed; 561 AA.
AC F4JPE9; F4JPE8; O22992; Q9T0A9;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=SUN domain-containing protein 5 {ECO:0000305};
DE Short=AtSUN5 {ECO:0000303|PubMed:25217773};
GN Name=SUN5 {ECO:0000303|PubMed:25217773};
GN OrderedLocusNames=At4g23950 {ECO:0000312|Araport:AT4G23950};
GN ORFNames=T19F6.21 {ECO:0000312|EMBL:AAB63627.1},
GN T32A16.120 {ECO:0000312|EMBL:CAB43895.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP SUBUNIT, INTERACTION WITH SUN3 AND TIK, AND DISRUPTION PHENOTYPE.
RX PubMed=25217773; DOI=10.1093/jxb/eru368;
RA Graumann K., Vanrobays E., Tutois S., Probst A.V., Evans D.E., Tatout C.;
RT "Characterization of two distinct subfamilies of SUN-domain proteins in
RT Arabidopsis and their interactions with the novel KASH-domain protein
RT AtTIK.";
RL J. Exp. Bot. 65:6499-6512(2014).
RN [4]
RP REVIEW.
RX PubMed=25740919; DOI=10.1093/jxb/erv082;
RA Zhou X., Graumann K., Meier I.;
RT "The plant nuclear envelope as a multifunctional platform LINCed by SUN and
RT KASH.";
RL J. Exp. Bot. 66:1649-1659(2015).
CC -!- FUNCTION: Encodes a member of the mid-SUN subfamily of SUN-domain
CC proteins. It is involved in early seed development and nuclear
CC morphology. [TAIR].
CC -!- SUBUNIT: Forms homomers. Interacts with SUN3 and TIK.
CC {ECO:0000269|PubMed:25217773}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4JPE9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4JPE9-2; Sequence=VSP_059088;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Embryo lethal when
CC associated with disruption mutants SUN3 and SUN4.
CC {ECO:0000269|PubMed:25217773}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB63627.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB43895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002343; AAB63627.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL078468; CAB43895.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161560; CAB81313.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84831.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84832.1; -; Genomic_DNA.
DR PIR; T08914; T08914.
DR RefSeq; NP_001190819.1; NM_001203890.1. [F4JPE9-2]
DR RefSeq; NP_194126.5; NM_118527.6. [F4JPE9-1]
DR AlphaFoldDB; F4JPE9; -.
DR SMR; F4JPE9; -.
DR STRING; 3702.AT4G23950.2; -.
DR PRIDE; F4JPE9; -.
DR ProteomicsDB; 226546; -. [F4JPE9-1]
DR EnsemblPlants; AT4G23950.1; AT4G23950.1; AT4G23950. [F4JPE9-1]
DR EnsemblPlants; AT4G23950.2; AT4G23950.2; AT4G23950. [F4JPE9-2]
DR GeneID; 828495; -.
DR Gramene; AT4G23950.1; AT4G23950.1; AT4G23950. [F4JPE9-1]
DR Gramene; AT4G23950.2; AT4G23950.2; AT4G23950. [F4JPE9-2]
DR KEGG; ath:AT4G23950; -.
DR Araport; AT4G23950; -.
DR TAIR; locus:2138156; AT4G23950.
DR eggNOG; KOG1396; Eukaryota.
DR OMA; RENYCKV; -.
DR OrthoDB; 1550835at2759; -.
DR PRO; PR:F4JPE9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JPE9; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; HDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0043621; F:protein self-association; IPI:UniProtKB.
DR GO; GO:0006997; P:nucleus organization; IGI:TAIR.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR045120; Suco/Slp1-like.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12953; PTHR12953; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51469; SUN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..561
FT /note="SUN domain-containing protein 5"
FT /id="PRO_0000441680"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..521
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 158..318
FT /note="SUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT REGION 345..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 454..499
FT /evidence="ECO:0000305"
FT VAR_SEQ 454
FT /note="M -> MQ (in isoform 2)"
FT /id="VSP_059088"
SQ SEQUENCE 561 AA; 63594 MW; 9DB9C0D16BF35FC7 CRC64;
MARRGSCSTI CLNEKLQRFR IVRISDKADN FNSRSGSFFE RSISLVLLLW CFLFLVYSKL
GQSHDDYGNA DRIGNYTDGS VSKTLNSTSS VFPQATEKEN NFCLLRKGQL QDVYEHVLVN
NALLICKVVL PERRISKKTL EARDPRYVNL EDKSLKVNGS SQLVNNGTRY RLEPDGNGYN
YASAMKGAKV VDHNKEAKGA SNVLGKDHDK YLRNPCSVSD KYVVIELAEE TLVDTVRIAN
FEHYSSNPKE FSLSGSLSFP SDMWTPAGSF AAANVKQIQS FRLPEPKWLR YLKLNLVSHY
GSEFYCTLSV VEVFGIDALE QMLEDLFVPS ETPPSKPAMV ELKTADEKQD GEIKSNRTDQ
IGKETEAQKK KDDVVKTINI IGDKKYEVKE KHNVLKVMMQ KVKLIEMNLS LLEDSVKKMN
DKQPEVSLEM KKTLVLVEKS KADIREITEW KGKMEKELRD LELWKTLVAS RVESLARGNS
ALRLDVEKIV KEQANLESKE LGVLLISLFF VVLATIRLVS TRLWAFLGMS ITDKARSLWP
DSGWVMILLS SSIMIFIHLL S
