ID   SUNA_BPSPB              Reviewed;          56 AA.
AC   P68578; O34781; O64033;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   02-DEC-2020, entry version 46.
DE   RecName: Full=Bacteriocin sublancin-168;
DE   Flags: Precursor;
GN   Name=sunA; OrderedLocusNames=SPBc2p020;
OS   Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Spbetavirus.
OX   NCBI_TaxID=66797;
OH   NCBI_TaxID=1408; Bacillus pumilus (Bacillus mesentericus).
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10376821; DOI=10.1099/13500872-145-5-1055;
RA   Lazarevic V., Duesterhoeft A., Soldo B., Hilbert H., Mauel C., Karamata D.;
RT   "Nucleotide sequence of the Bacillus subtilis temperate bacteriophage
RT   SPbetac2.";
RL   Microbiology 145:1055-1067(1999).
CC   -!- FUNCTION: Bacteriocin active against Gram-positive bacteria. Inhibits
CC       B.cereus spore outgrowth, after the germination stage, approximately
CC       1000-fold better than it inhibits exponential growth of the same cells.
CC       Inhibits B.subtilis strain ATCC 6633. {ECO:0000250|UniProtKB:P68577}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P68577}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P68577}.
CC       Note=Extracellular region. {ECO:0000250|UniProtKB:P68577}.
CC   -!- PTM: Production of active sublancin-168 requires at least one thiol-
CC       disulfide oxidoreductase (BdbB or, in its absence, BdbC). Membrane
CC       translocation and cleavage of the precursor are probably performed by
CC       SunT. {ECO:0000250|UniProtKB:P68577}.
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DR   EMBL; AF020713; AAC12992.1; -; Genomic_DNA.
DR   PIR; T12783; T12783.
DR   RefSeq; NP_046571.1; NC_001884.1.
DR   BMRB; P68578; -.
DR   SMR; P68578; -.
DR   GeneID; 1261375; -.
DR   KEGG; vg:1261375; -.
DR   Proteomes; UP000009091; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR026479; Glycopep_SunS.
DR   Pfam; PF19151; Sublancin; 1.
DR   TIGRFAMs; TIGR04196; glycopep_SunS; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriocin; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted.
FT   PROPEP          1..19
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000017146"
FT   PEPTIDE         20..56
FT                   /note="Bacteriocin sublancin-168"
FT                   /id="PRO_0000017147"
FT   CARBOHYD        41
FT                   /note="S-linked (Glc) cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P68577"
FT   DISULFID        26..55
FT                   /evidence="ECO:0000250|UniProtKB:P68577"
FT   DISULFID        33..48
FT                   /evidence="ECO:0000250|UniProtKB:P68577"
SQ   SEQUENCE   56 AA;  5982 MW;  79EC0BF822F9F4C0 CRC64;
     MEKLFKEVKL EELENQKGSG LGKAQCAALW LQCASGGTIG CGGGAVACQN YRQFCR