SUNS_BACSU
ID SUNS_BACSU Reviewed; 422 AA.
AC O31986; Q7BVG7;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=SPbeta prophage-derived glycosyltransferase SunS;
DE EC=2.4.1.-;
GN Name=sunS; Synonyms=yolJ; OrderedLocusNames=BSU21450;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 86-422.
RC STRAIN=168;
RX PubMed=9579063; DOI=10.1099/00221287-144-4-885;
RA Regamey A., Karamata D.;
RT "The N-acetylmuramoyl-L-alanine amidase encoded by the Bacillus subtilis
RT 168 prophage SP beta.";
RL Microbiology 144:885-893(1998).
RN [3]
RP FUNCTION AS A GLYCOSYLTRANSFERASE.
RC STRAIN=168;
RX PubMed=21196935; DOI=10.1038/nchembio.509;
RA Oman T.J., Boettcher J.M., Wang H., Okalibe X.N., van der Donk W.A.;
RT "Sublancin is not a lantibiotic but an S-linked glycopeptide.";
RL Nat. Chem. Biol. 7:78-80(2011).
CC -!- FUNCTION: Transfers a hexose moiety onto 'Cys-41' of bacteriocin
CC sublancin-168 (SunA). Accepts UDP-glucose (UDP-Glc), UDP-N-
CC acetylglucosamine (UDP-GlcNAc), UDP-galactose (UDP-Gal), UDP-xylose
CC (UDP-Xyl) and GDP-mannose as substrate. {ECO:0000269|PubMed:21196935}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR EMBL; AL009126; CAB14063.1; -; Genomic_DNA.
DR EMBL; AF021803; AAC38304.1; -; Genomic_DNA.
DR RefSeq; NP_390028.1; NC_000964.3.
DR RefSeq; WP_004399050.1; NZ_JNCM01000036.1.
DR PDB; 7MSN; X-ray; 3.00 A; A/B=1-422.
DR PDB; 7MSP; X-ray; 2.10 A; A/B=1-335.
DR PDBsum; 7MSN; -.
DR PDBsum; 7MSP; -.
DR AlphaFoldDB; O31986; -.
DR SMR; O31986; -.
DR STRING; 224308.BSU21450; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR jPOST; O31986; -.
DR PaxDb; O31986; -.
DR PRIDE; O31986; -.
DR EnsemblBacteria; CAB14063; CAB14063; BSU_21450.
DR GeneID; 939123; -.
DR KEGG; bsu:BSU21450; -.
DR PATRIC; fig|224308.179.peg.2342; -.
DR eggNOG; COG0463; Bacteria.
DR InParanoid; O31986; -.
DR OMA; ATSEWIY; -.
DR PhylomeDB; O31986; -.
DR BioCyc; BSUB:BSU21450-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IDA:UniProtKB.
DR GO; GO:0030152; P:bacteriocin biosynthetic process; IDA:UniProtKB.
DR GO; GO:0018240; P:protein S-linked glycosylation via cysteine; IDA:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR026499; S_glycosyl_SunS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR04195; S_glycosyl_SunS; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..422
FT /note="SPbeta prophage-derived glycosyltransferase SunS"
FT /id="PRO_0000360810"
SQ SEQUENCE 422 AA; 49765 MW; EACF1D50F792C014 CRC64;
MKLSDIYLEL KKGYADSLLY SDLSLLVNIM EYEKDIDVMS IQSLVAGYEK SDTPTITCGI
IVYNESKRIK KCLNSVKDDF NEIIVLDSYS TDDTVDIIKC DFPDVEIKYE KWKNDFSYAR
NKIIEYATSE WIYFIDADNL YSKENKGKIA KVARVLEFFS IDCVVSPYIE EYTGHLYSDT
RRMFRLNGKV KFHGKVHEEP MNYNHSLPFN FIVNLKVYHN GYNPSENNIK SKTRRNINLT
EEMLRLEPEN PKWLFFFGRE LHLLDKDEEA IDYLKKSINN YKKFNDQRHF IDALVLLCTL
LLQRNNYVDL TLYLDILETE YPRCVDVDYF RSAILLVDMQ NKLTSLSNMI DEALTDERYS
AINTTKDHFK RILISLNIQL ENWERVKEIS GEIKNDNMKK EIKQYLANSL HNIEHVLKGI
EV
