ID   SUPYN_HUMAN             Reviewed;         160 AA.
AC   M5A8F1;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Suppressyn;
DE   AltName: Full=Endogenous retrovirus group 48 member 1;
DE   AltName: Full=NDUFV3 antisense RNA 1;
DE   AltName: Full=endogenous retrovirus group Fb member 1;
DE   Flags: Precursor;
GN   Name=ERVH48-1; Synonyms=C21orf105, HERV-Fb1, NDUFV3-AS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SLC1A5, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   PubMed=23492904; DOI=10.1038/srep01462;
RA   Sugimoto J., Sugimoto M., Bernstein H., Jinno Y., Schust D.;
RT   "A novel human endogenous retroviral protein inhibits cell-cell fusion.";
RL   Sci. Rep. 3:1462-1462(2013).
CC   -!- FUNCTION: May play a role in trophoblasts syncytialization, the
CC       spontaneous fusion of their plasma membranes, an essential process in
CC       placental development. May negatively regulate cell-cell fusion by
CC       interacting with SLC1A5, the probable receptor on the cell surface of
CC       the fusogenic syncytin-1/ERVW-1. {ECO:0000269|PubMed:23492904}.
CC   -!- SUBUNIT: Interacts (secreted) with SLC1A5; mainly at cell surface.
CC       {ECO:0000269|PubMed:23492904}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23492904}. Note=Also
CC       found in cell lysates.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in placenta by extravillous
CC       trophoblasts and syncytiotrophoblasts (at protein level).
CC       {ECO:0000269|PubMed:23492904}.
CC   -!- MISCELLANEOUS: The human genome contains a high percentage of proviral-
CC       like elements, also called endogenous retroviruses (ERVs) that are the
CC       genomic traces of ancient infections of the germline by exogenous
CC       retroviruses. Although most of these elements are defective, some have
CC       conserved a functional envelope (env) gene, most probably diverted by
CC       the host for its benefit.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB610407; BAN04646.1; -; mRNA.
DR   RefSeq; NP_001295420.1; NM_001308491.1.
DR   AlphaFoldDB; M5A8F1; -.
DR   BioMuta; HGNC:17216; -.
DR   EPD; M5A8F1; -.
DR   MassIVE; M5A8F1; -.
DR   PeptideAtlas; M5A8F1; -.
DR   PRIDE; M5A8F1; -.
DR   DNASU; 90625; -.
DR   Ensembl; ENST00000447535.2; ENSP00000504647.1; ENSG00000233056.4.
DR   GeneID; 90625; -.
DR   KEGG; hsa:90625; -.
DR   MANE-Select; ENST00000447535.2; ENSP00000504647.1; NM_001308491.2; NP_001295420.1.
DR   CTD; 90625; -.
DR   DisGeNET; 90625; -.
DR   GeneCards; ERVH48-1; -.
DR   HGNC; HGNC:17216; ERVH48-1.
DR   HPA; ENSG00000233056; Tissue enriched (placenta).
DR   neXtProt; NX_M5A8F1; -.
DR   OpenTargets; ENSG00000233056; -.
DR   VEuPathDB; HostDB:ENSG00000233056; -.
DR   GeneTree; ENSGT01000000215029; -.
DR   OMA; NGAICPQ; -.
DR   OrthoDB; 1320409at2759; -.
DR   PathwayCommons; M5A8F1; -.
DR   SignaLink; M5A8F1; -.
DR   BioGRID-ORCS; 90625; 0 hits in 7 CRISPR screens.
DR   GenomeRNAi; 90625; -.
DR   Pharos; M5A8F1; Tdark.
DR   PRO; PR:M5A8F1; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; M5A8F1; protein.
DR   Bgee; ENSG00000233056; Expressed in placenta and 105 other tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0006949; P:syncytium formation; IMP:UniProtKB.
PE   1: Evidence at protein level;
KW   ERV; Reference proteome; Secreted; Signal; Transposable element.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000255"
FT   CHAIN           40..160
FT                   /note="Suppressyn"
FT                   /id="PRO_0000430056"
FT   REGION          137..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   160 AA;  18128 MW;  9D4F8B810EE9583A CRC64;
     MACIYPTTFY TSLPTKSLNM GISLTTILIL SVAVLLSTAA PPSCRECYQS LHYRGEMQQY
     FTYHTHIERS CYGNLIEECV ESGKSYYKVK NLGVCGSRNG AICPRGKQWL CFTKIGQWGV
     NTQVLEDIKR EQIIAKAKAS KPTTPPENRP RHFHSFIQKL