SUR8_CULQU
ID SUR8_CULQU Reviewed; 628 AA.
AC B0W6M9;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE AltName: Full=Protein Sur-8 homolog;
DE AltName: Full=Protein soc-2 homolog;
GN Name=Sur-8; ORFNames=CPIJ002780;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR EMBL; DS231848; EDS36703.1; -; Genomic_DNA.
DR RefSeq; XP_001844363.1; XM_001844311.1.
DR AlphaFoldDB; B0W6M9; -.
DR SMR; B0W6M9; -.
DR STRING; 7176.CPIJ002780-PA; -.
DR EnsemblMetazoa; XM_038256491.1; XP_038112419.1; LOC6033975.
DR GeneID; 6033975; -.
DR KEGG; cqu:CpipJ_CPIJ002780; -.
DR VEuPathDB; VectorBase:CPIJ002780; -.
DR VEuPathDB; VectorBase:CQUJHB010957; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; B0W6M9; -.
DR OMA; NQFTSYP; -.
DR OrthoDB; 287114at2759; -.
DR PhylomeDB; B0W6M9; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 16.
DR PROSITE; PS51450; LRR; 18.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..628
FT /note="Leucine-rich repeat protein soc-2 homolog"
FT /id="PRO_0000385633"
FT REPEAT 148..169
FT /note="LRR 1"
FT REPEAT 171..192
FT /note="LRR 2"
FT REPEAT 194..216
FT /note="LRR 3"
FT REPEAT 217..238
FT /note="LRR 4"
FT REPEAT 240..262
FT /note="LRR 5"
FT REPEAT 263..284
FT /note="LRR 6"
FT REPEAT 286..307
FT /note="LRR 7"
FT REPEAT 309..330
FT /note="LRR 8"
FT REPEAT 332..353
FT /note="LRR 9"
FT REPEAT 355..376
FT /note="LRR 10"
FT REPEAT 379..400
FT /note="LRR 11"
FT REPEAT 403..424
FT /note="LRR 12"
FT REPEAT 427..448
FT /note="LRR 13"
FT REPEAT 450..471
FT /note="LRR 14"
FT REPEAT 473..494
FT /note="LRR 15"
FT REPEAT 496..517
FT /note="LRR 16"
FT REPEAT 519..540
FT /note="LRR 17"
FT REPEAT 542..563
FT /note="LRR 18"
FT REPEAT 565..587
FT /note="LRR 19"
FT REPEAT 589..610
FT /note="LRR 20"
FT REGION 23..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 68979 MW; 22165F00FF63C566 CRC64;
MGLCHSNCPF VEQKCHRIKV SRPTEGGVWP TTNGFSLDHT TKSAKTLGRT RTTSPKTNER
GMNLGSSGGT STSGHTSSGY SSGNAPGTSS SSTGGGATSS EMPAEIRPKV VTVKHPESNK
PKPTTKKGKA IQADVDVIKE FQRCKEENIL RLDLSKSSIT VIPPSVKDCT SLIEFYLYGN
KISSLPVEIG CLSNLKTLAL NENSLTSLPD SLQNLKALKV LDLRHNKLSE IPDVIYKLHT
LTTLYLRFNR IKVVGDNLKN LSSLTMLSLR ENKIHELPAA IGHLRNLTTL DLSHNHLKHL
PEAIGNCVNL TALDLQHNDL LDIPETIGNL ANLQRLGLRY NQLTAIPVSL RNCIHMDEFN
VEGNSISQLP DGLLASLSNL TTITLSRNAF HSYPSGGPAQ FTNVTSINME HNQIDKIQYG
IFSRAKGLTK LNMKENALTS LPLDIGTWSQ MVELNFGTNS LAKLPDDIHC LQNLEILILS
NNMLKRIPNT IGNLKKLRVL DLEENRLESL PSEIGLLHDL QKLILQSNAL QSLPRTIGHL
TNLTYLSVGE NNLQYLPEEI GTLENLESLY INDNASLVKL PYELALCQNL AIMSIENCPL
SALPPEVVGG GPSLVIQYLK LHSPYRQM
