SUR8_DROGR
ID SUR8_DROGR Reviewed; 622 AA.
AC B4JTV9;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE AltName: Full=Protein Sur-8 homolog;
DE AltName: Full=Protein soc-2 homolog;
GN Name=Sur-8; ORFNames=GH17496;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR EMBL; CH916374; EDV91538.1; -; Genomic_DNA.
DR RefSeq; XP_001994909.1; XM_001994873.1.
DR AlphaFoldDB; B4JTV9; -.
DR SMR; B4JTV9; -.
DR STRING; 7222.FBpp0151402; -.
DR EnsemblMetazoa; FBtr0152910; FBpp0151402; FBgn0124966.
DR GeneID; 6568108; -.
DR KEGG; dgr:6568108; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; B4JTV9; -.
DR OMA; NQFTSYP; -.
DR OrthoDB; 287114at2759; -.
DR PhylomeDB; B4JTV9; -.
DR ChiTaRS; Sur-8; fly.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 15.
DR PROSITE; PS51450; LRR; 18.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..622
FT /note="Leucine-rich repeat protein soc-2 homolog"
FT /id="PRO_0000385636"
FT REPEAT 142..163
FT /note="LRR 1"
FT REPEAT 165..186
FT /note="LRR 2"
FT REPEAT 188..209
FT /note="LRR 3"
FT REPEAT 211..232
FT /note="LRR 4"
FT REPEAT 234..255
FT /note="LRR 5"
FT REPEAT 257..278
FT /note="LRR 6"
FT REPEAT 280..301
FT /note="LRR 7"
FT REPEAT 303..324
FT /note="LRR 8"
FT REPEAT 326..348
FT /note="LRR 9"
FT REPEAT 349..370
FT /note="LRR 10"
FT REPEAT 373..394
FT /note="LRR 11"
FT REPEAT 397..418
FT /note="LRR 12"
FT REPEAT 421..442
FT /note="LRR 13"
FT REPEAT 444..465
FT /note="LRR 14"
FT REPEAT 467..488
FT /note="LRR 15"
FT REPEAT 490..511
FT /note="LRR 16"
FT REPEAT 513..534
FT /note="LRR 17"
FT REPEAT 536..557
FT /note="LRR 18"
FT REPEAT 559..581
FT /note="LRR 19"
FT REPEAT 583..604
FT /note="LRR 20"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 67909 MW; E1860CB573C63EF6 CRC64;
MNLCSSSGAT ASNTSLSSTG HPESNGSGPS EATHCFGGGG GGGGNNAGGG SGTDTAPNSN
KGTLNGGGSG GGGGANPASS NGHSLTHNNE NNGNMPPETR PKMVTVKHPE SNKPKPTTKK
IVKNIQADQD VIKALQRCRD EGIKRLDLSK SSITVLPNTV RECVHLTELY LYSNKIGQLP
TEIGCLVNLR NLALNENSLT SLPESLKHCT QLKVLDLRHN KLAEIPSVIY RLRSLTTLYL
RFNRITTVAD DLRQLVNLTM LSLRENKIKE LGSAIGALVN LTTLDVSHNH LEHLPEDIGN
CVNLSALDLQ HNELLDIPDS IGNLKSLVRL GLRYNRLNCV PVSLKNCKSM DEFNVEGNGI
TQLPDGMLAS LSALTSITLS RNQFTSYPTG GPAQFTNVYS INLEHNRIDK IPYGIFSRAK
GLTKLNMKEN MLTALPLDVG TWVNMVELNL ATNALQKLPD DIMNLQNLEI LILSNNMLKK
IPNTIGNLRK LRILDLEENR IEVLPHEIGL LHELQRLILQ TNQITMLPRS VGHLSNLTHL
SVSENNLQFL PEEIGSLESL ENLYINQNPG LEKLPFELAL CQNLKYLNID KCPLGTIPPE
IQAGGPSLVL QWLKMHSPYR QM
