SUR8_DROME
ID SUR8_DROME Reviewed; 641 AA.
AC Q9VEK6; Q86PB5; Q8MQM0;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE AltName: Full=Protein Sur-8 homolog;
DE AltName: Full=Protein soc-2 homolog;
GN Name=Sur-8; ORFNames=CG5407;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INABILITY TO ACTIVATE THE ERK PATHWAY.
RX PubMed=11741918; DOI=10.1074/jbc.m110498200;
RA Anselmo A.N., Bumeister R., Thomas J.M., White M.A.;
RT "Critical contribution of linker proteins to Raf kinase activation.";
RL J. Biol. Chem. 277:5940-5943(2002).
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9VEK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9VEK6-2; Sequence=VSP_038199;
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
CC -!- CAUTION: In their assays, PubMed:11741918 could not detect any effect
CC on activation of the ERK pathway. {ECO:0000305}.
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DR EMBL; AE014297; AAF55415.3; -; Genomic_DNA.
DR EMBL; AE014297; AAN13743.2; -; Genomic_DNA.
DR EMBL; AY128499; AAM75092.1; -; mRNA.
DR EMBL; BT003235; AAO24991.1; -; mRNA.
DR RefSeq; NP_001262664.1; NM_001275735.1. [Q9VEK6-1]
DR RefSeq; NP_650620.3; NM_142363.7. [Q9VEK6-1]
DR RefSeq; NP_732231.2; NM_169758.4. [Q9VEK6-1]
DR AlphaFoldDB; Q9VEK6; -.
DR SMR; Q9VEK6; -.
DR BioGRID; 67129; 4.
DR IntAct; Q9VEK6; 1.
DR STRING; 7227.FBpp0082888; -.
DR PaxDb; Q9VEK6; -.
DR PRIDE; Q9VEK6; -.
DR DNASU; 42093; -.
DR EnsemblMetazoa; FBtr0083447; FBpp0082888; FBgn0038504. [Q9VEK6-1]
DR EnsemblMetazoa; FBtr0083448; FBpp0082889; FBgn0038504. [Q9VEK6-1]
DR EnsemblMetazoa; FBtr0339532; FBpp0308615; FBgn0038504. [Q9VEK6-1]
DR GeneID; 42093; -.
DR KEGG; dme:Dmel_CG5407; -.
DR UCSC; CG5407-RA; d. melanogaster. [Q9VEK6-1]
DR CTD; 42093; -.
DR FlyBase; FBgn0038504; Sur-8.
DR VEuPathDB; VectorBase:FBgn0038504; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000166939; -.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; Q9VEK6; -.
DR OMA; NQFTSYP; -.
DR PhylomeDB; Q9VEK6; -.
DR SignaLink; Q9VEK6; -.
DR BioGRID-ORCS; 42093; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Sur-8; fly.
DR GenomeRNAi; 42093; -.
DR PRO; PR:Q9VEK6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038504; Expressed in embryonic/larval hemocyte (Drosophila) and 28 other tissues.
DR ExpressionAtlas; Q9VEK6; baseline and differential.
DR Genevisible; Q9VEK6; DM.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; HGI:FlyBase.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 15.
DR PROSITE; PS51450; LRR; 18.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..641
FT /note="Leucine-rich repeat protein soc-2 homolog"
FT /id="PRO_0000385637"
FT REPEAT 161..182
FT /note="LRR 1"
FT REPEAT 184..205
FT /note="LRR 2"
FT REPEAT 207..228
FT /note="LRR 3"
FT REPEAT 230..251
FT /note="LRR 4"
FT REPEAT 253..274
FT /note="LRR 5"
FT REPEAT 276..297
FT /note="LRR 6"
FT REPEAT 299..320
FT /note="LRR 7"
FT REPEAT 322..343
FT /note="LRR 8"
FT REPEAT 345..367
FT /note="LRR 9"
FT REPEAT 368..389
FT /note="LRR 10"
FT REPEAT 392..413
FT /note="LRR 11"
FT REPEAT 416..437
FT /note="LRR 12"
FT REPEAT 440..461
FT /note="LRR 13"
FT REPEAT 463..484
FT /note="LRR 14"
FT REPEAT 486..507
FT /note="LRR 15"
FT REPEAT 509..530
FT /note="LRR 16"
FT REPEAT 532..553
FT /note="LRR 17"
FT REPEAT 555..576
FT /note="LRR 18"
FT REPEAT 578..600
FT /note="LRR 19"
FT REPEAT 602..623
FT /note="LRR 20"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_038199"
SQ SEQUENCE 641 AA; 69372 MW; 1C0DD15B26EB975A CRC64;
MNLCSSGATA STTSLSSTGQ AERSGGVPGG GAEGGGGSGN SGGGGKTSNG SAEAPTLCFA
GGSGTAGAIA GTEELSNANS PANGAGGATG STGSGQQPTG SNGHSHLHNE NNANMPPETR
PKMVTVKHPE SNKPKPTTKK SKPIQADQDV IKALQRCRDE GIKRLDLSKS SITVIPSTVK
ECVHLTELYL YSNKIGQLPP EIGCLVSLRN LALNENSLTS LPESLQNCSQ LKVLDLRHNK
LAEIPPVIYR LRSLTTLYLR FNRITAVADD LRQLVNLTML SLRENKIREL GSAIGALVNL
TTLDVSHNHL EHLPEDIGNC VNLSALDLQH NELLDIPDSI GNLKSLVRLG MRYNRLSSVP
ATLKNCKSMD EFNVEGNGIT QLPDGMLASL SGLTTITLSR NQFASYPTGG PAQFTNVYSI
NLEHNRIDKI PYGIFSRAKG LTKLNMKENM LTALPLDIGT WVNMVELNLA TNALQKLPDD
IMNLQNLEIL ILSNNMLKKI PNTIGNLRKL RILDLEENRI EVLPHEIGLL HELQRLILQT
NQITMLPRSI GHLGNLTHLS VSENNLQFLP EEIGSLESLE NLYINQNPGL EKLPFELALC
QNLKYLNIDK CPLSTIPPEI QAGGPSLVLQ WLKMHSPYRQ M
