SUR8_DROPS
ID SUR8_DROPS Reviewed; 629 AA.
AC B5DX45;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE AltName: Full=Protein Sur-8 homolog;
DE AltName: Full=Protein soc-2 homolog;
GN Name=Sur-8; ORFNames=GA27118;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR EMBL; CM000070; EDY67848.1; -; Genomic_DNA.
DR AlphaFoldDB; B5DX45; -.
DR SMR; B5DX45; -.
DR STRING; 7237.FBpp0283635; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; B5DX45; -.
DR OMA; NQFTSYP; -.
DR ChiTaRS; Sur-8; fly.
DR Proteomes; UP000001819; Genome assembly.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR SMART; SM00369; LRR_TYP; 14.
DR PROSITE; PS51450; LRR; 19.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..629
FT /note="Leucine-rich repeat protein soc-2 homolog"
FT /id="PRO_0000385638"
FT REPEAT 149..170
FT /note="LRR 1"
FT REPEAT 172..193
FT /note="LRR 2"
FT REPEAT 195..217
FT /note="LRR 3"
FT REPEAT 218..239
FT /note="LRR 4"
FT REPEAT 241..262
FT /note="LRR 5"
FT REPEAT 264..285
FT /note="LRR 6"
FT REPEAT 287..308
FT /note="LRR 7"
FT REPEAT 310..331
FT /note="LRR 8"
FT REPEAT 333..355
FT /note="LRR 9"
FT REPEAT 356..377
FT /note="LRR 10"
FT REPEAT 380..401
FT /note="LRR 11"
FT REPEAT 404..425
FT /note="LRR 12"
FT REPEAT 428..449
FT /note="LRR 13"
FT REPEAT 451..472
FT /note="LRR 14"
FT REPEAT 474..495
FT /note="LRR 15"
FT REPEAT 497..518
FT /note="LRR 16"
FT REPEAT 520..541
FT /note="LRR 17"
FT REPEAT 543..564
FT /note="LRR 18"
FT REPEAT 566..588
FT /note="LRR 19"
FT REPEAT 590..611
FT /note="LRR 20"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 68544 MW; 5B3E26323D0496FA CRC64;
MNLCSSGATA STTSLSSTGQ RNGGTSEGGG EGAGGGGGSG GGGGNSSNDG PSEAIHCFGS
NGGGGGPEEV FHTSHSHSTA NGGGGGGSSN GHSQQHNENN ATMPPETRPK MVTVKHPESN
KPKPTTKKSK PIQADQDVIK ALQRCRDEGI KRLDLSKSSI TVIPSTVKEC VHLTELYLYS
NKIGQLPAEI GCLVNLRNLA LNENSLTSLP ESLQNCKQLK VLDLRHNKLA EIPPVIYRLR
TLTTLYLRFN RITAVADNLR QLVNLTMLSL RENKIRELGS AIGALVNLTT LDVSHNHLEH
LPEDIGNCVN LSALDLQHNE LLDIPDSIGN LKSLVRLGLR YNRLSSVPAT LKNCKSMDEF
NVEGNGMTQL PDGMLASLSG LTTITLSRNQ FTSYPTGGPA QFTNVYSINL EHNRIDKIPY
GIFSRAKGLT KLNMKENMLT ALPLDIGTWV NMVELNLATN ALQKLPDDIM NLQNLEILIL
SNNMLKKIPN TIGNMRKLRI LDLEENRIEV LPHEIGLLHE LQRLILQTNQ ITMLPRSIGH
LSNLTHLSVS ENNLQFLPEE IGSLEGLENL YINQNPGLEK LPFELALCQN LKYLNIDKCP
LSTIPPEIQA GGPSLVLQWL KMHSPYRQM
