ID   SUR8_DROSE              Reviewed;         683 AA.
AC   B4IBI9;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE   AltName: Full=Protein Sur-8 homolog;
DE   AltName: Full=Protein soc-2 homolog;
GN   Name=Sur-8; ORFNames=GM15368;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC       activation. Probably acts as a regulatory subunit of protein
CC       phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC       Raf activity at specialized signaling complexes upon Ras activation (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH480827; EDW44747.1; -; Genomic_DNA.
DR   RefSeq; XP_002041099.1; XM_002041063.1.
DR   AlphaFoldDB; B4IBI9; -.
DR   SMR; B4IBI9; -.
DR   STRING; 7238.B4IBI9; -.
DR   EnsemblMetazoa; FBtr0198353; FBpp0196845; FBgn0170287.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   OMA; NQFTSYP; -.
DR   PhylomeDB; B4IBI9; -.
DR   ChiTaRS; Sur-8; fly.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 15.
DR   PROSITE; PS51450; LRR; 18.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..683
FT                   /note="Leucine-rich repeat protein soc-2 homolog"
FT                   /id="PRO_0000385639"
FT   REPEAT          164..185
FT                   /note="LRR 1"
FT   REPEAT          187..208
FT                   /note="LRR 2"
FT   REPEAT          210..231
FT                   /note="LRR 3"
FT   REPEAT          233..254
FT                   /note="LRR 4"
FT   REPEAT          256..277
FT                   /note="LRR 5"
FT   REPEAT          279..300
FT                   /note="LRR 6"
FT   REPEAT          302..323
FT                   /note="LRR 7"
FT   REPEAT          325..346
FT                   /note="LRR 8"
FT   REPEAT          348..370
FT                   /note="LRR 9"
FT   REPEAT          371..392
FT                   /note="LRR 10"
FT   REPEAT          395..416
FT                   /note="LRR 11"
FT   REPEAT          419..440
FT                   /note="LRR 12"
FT   REPEAT          443..464
FT                   /note="LRR 13"
FT   REPEAT          466..487
FT                   /note="LRR 14"
FT   REPEAT          489..510
FT                   /note="LRR 15"
FT   REPEAT          512..533
FT                   /note="LRR 16"
FT   REPEAT          535..556
FT                   /note="LRR 17"
FT   REPEAT          558..579
FT                   /note="LRR 18"
FT   REPEAT          581..603
FT                   /note="LRR 19"
FT   REPEAT          605..626
FT                   /note="LRR 20"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  73395 MW;  1C641BA30ACA7228 CRC64;
     MNLCSSGATA STTSLSSTGQ AERSGGVPGG GAEGGGGGGG SGNSGGGGKT SDVSAEASTL
     CFAGGSGTAG AITGTDELSN ANSPANGAGG ASGSTGSAQQ PTGSNGHSHL HNENNANMPP
     ETRPKMVTVK HPESNKPKPT TKKSKPIQAD QDVIKALQRC RDEGIKRLDL SKSSITVIPS
     TVKECVHLTE LYLYSNKIGQ LPPEIGCLVS LRNLALNENS LTSLPESLQN CSQLKVLDLR
     HNKLAEIPSV IYRLRSLTTL YLRFNRITAV ADDLRQLVNL TMLSLRENKI RELGSAIGAL
     VNLTTLDVSH NHLEHLPEDI GNCVNLSALD LQHNELLDIP DSIGNLKSLV RLGMRYNRLS
     SVPATLKNCK SMDEFNVEGN GITQLPDGML ASLSGLTTIT LSRNQFASYP TGGPAQFTNV
     YSINLEHNRI DKIPYGIFSR AKGLTKLNMK ENMLTALPLD IGTWVNMVEL NLATNALQKL
     PDDIMNLQNL EILILSNNML KKIPNTIGNL RRLRILDLEE NRIEVLPHEI GLLHELQRLI
     LQTNQITMLP RSIGHLGNLT HLSVSENNLQ FLPEEIGSLE SLENLYINQN PGLEKLPFEL
     ALCQNLKYLN IDKCPLSTIP PEIQAGGPSL VLQWLKMHSP YRQIDCYYQY ELQTVNQAPG
     AGGNGGGGAA AAGGSASRSS DRR