ID   SUR8_DROVI              Reviewed;         614 AA.
AC   B4LXW1;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE   AltName: Full=Protein Sur-8 homolog;
DE   AltName: Full=Protein soc-2 homolog;
GN   Name=Sur-8; ORFNames=GJ22826;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC       activation. Probably acts as a regulatory subunit of protein
CC       phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC       Raf activity at specialized signaling complexes upon Ras activation (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; CH940650; EDW67920.1; -; Genomic_DNA.
DR   RefSeq; XP_002054400.2; XM_002054364.2.
DR   AlphaFoldDB; B4LXW1; -.
DR   SMR; B4LXW1; -.
DR   STRING; 7244.FBpp0237243; -.
DR   EnsemblMetazoa; FBtr0238751; FBpp0237243; FBgn0209930.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   InParanoid; B4LXW1; -.
DR   OMA; NQFTSYP; -.
DR   OrthoDB; 287114at2759; -.
DR   PhylomeDB; B4LXW1; -.
DR   ChiTaRS; Sur-8; fly.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 15.
DR   PROSITE; PS51450; LRR; 18.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..614
FT                   /note="Leucine-rich repeat protein soc-2 homolog"
FT                   /id="PRO_0000385641"
FT   REPEAT          134..155
FT                   /note="LRR 1"
FT   REPEAT          157..178
FT                   /note="LRR 2"
FT   REPEAT          180..201
FT                   /note="LRR 3"
FT   REPEAT          203..224
FT                   /note="LRR 4"
FT   REPEAT          226..247
FT                   /note="LRR 5"
FT   REPEAT          249..270
FT                   /note="LRR 6"
FT   REPEAT          272..293
FT                   /note="LRR 7"
FT   REPEAT          295..316
FT                   /note="LRR 8"
FT   REPEAT          318..340
FT                   /note="LRR 9"
FT   REPEAT          341..362
FT                   /note="LRR 10"
FT   REPEAT          365..386
FT                   /note="LRR 11"
FT   REPEAT          389..410
FT                   /note="LRR 12"
FT   REPEAT          413..434
FT                   /note="LRR 13"
FT   REPEAT          436..457
FT                   /note="LRR 14"
FT   REPEAT          459..480
FT                   /note="LRR 15"
FT   REPEAT          482..503
FT                   /note="LRR 16"
FT   REPEAT          505..526
FT                   /note="LRR 17"
FT   REPEAT          528..549
FT                   /note="LRR 18"
FT   REPEAT          551..573
FT                   /note="LRR 19"
FT   REPEAT          575..596
FT                   /note="LRR 20"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  67620 MW;  4F5044E662552DC5 CRC64;
     MNLCSSAGAT ASTSSLSSSG HVESNSSGPS EAIHCFGVVG GGGNSGGSGR ADTALNQSNR
     STVNGGGGNP TNSNGPNLTH NEINAIMPPE TRPKMVTVKH PESNKPKPTT KKIVKNIQAD
     QDVIKALQRC RDEGIKRLDL SKSSITVLPN TVRECVHLTE LYLYSNKIGQ LPTEIGCLVN
     LRNLALNENS LTSLPESLKH CTQLKVLDLR HNKLAEIPSV IYRLRSLTTL YLRFNRITAV
     ADDLRQLVNL TMLSLRENKI KELGSAIGAL VNLTTLDVSH NHLEHLPDDI GNCVNLSALD
     LQHNELLDIP DSIGNLKSLV RLGLRYNRLN SVPISLKNCK SMDEFNVEGN GITQLPDGML
     ASLSALTTIT LSRNQFTSYP TGGPAQFTNV YSINLEHNRI DKIPYGIFSR AKGLTKLNMK
     ENMLTALPLD VGTWVNMVEL NLATNALQKL PDDIMNLQNL EILILSNNML KKIPNTIGNL
     RKLRILDLEE NRIEVLPHEI GLLHELQRLI LQTNQITMLP RSIGHLSNLT HLSVSENNLQ
     FLPEEIGSLE SLENLYINQN PGLEKLPFEL ALCQNLKYLN IDKCPLGTIP PEIQAGGPSL
     VLQWLKMHSP YRQM