ID   SUR8_DROWI              Reviewed;         641 AA.
AC   B4N9T4;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE   AltName: Full=Protein Sur-8 homolog;
DE   AltName: Full=Protein soc-2 homolog;
GN   Name=Sur-8; ORFNames=GK11454;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC       activation. Probably acts as a regulatory subunit of protein
CC       phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC       Raf activity at specialized signaling complexes upon Ras activation (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR   EMBL; CH964232; EDW80649.1; -; Genomic_DNA.
DR   RefSeq; XP_002069663.2; XM_002069627.2.
DR   AlphaFoldDB; B4N9T4; -.
DR   SMR; B4N9T4; -.
DR   STRING; 7260.FBpp0240597; -.
DR   EnsemblMetazoa; FBtr0242105; FBpp0240597; FBgn0213465.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_000288_18_23_1; -.
DR   InParanoid; B4N9T4; -.
DR   OMA; NQFTSYP; -.
DR   OrthoDB; 287114at2759; -.
DR   PhylomeDB; B4N9T4; -.
DR   ChiTaRS; Sur-8; fly.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027036; SHOC2.
DR   PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   SMART; SM00369; LRR_TYP; 15.
DR   PROSITE; PS51450; LRR; 19.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..641
FT                   /note="Leucine-rich repeat protein soc-2 homolog"
FT                   /id="PRO_0000385642"
FT   REPEAT          161..182
FT                   /note="LRR 1"
FT   REPEAT          184..205
FT                   /note="LRR 2"
FT   REPEAT          207..228
FT                   /note="LRR 3"
FT   REPEAT          230..251
FT                   /note="LRR 4"
FT   REPEAT          253..274
FT                   /note="LRR 5"
FT   REPEAT          276..297
FT                   /note="LRR 6"
FT   REPEAT          299..320
FT                   /note="LRR 7"
FT   REPEAT          322..343
FT                   /note="LRR 8"
FT   REPEAT          345..367
FT                   /note="LRR 9"
FT   REPEAT          368..389
FT                   /note="LRR 10"
FT   REPEAT          392..413
FT                   /note="LRR 11"
FT   REPEAT          416..437
FT                   /note="LRR 12"
FT   REPEAT          440..461
FT                   /note="LRR 13"
FT   REPEAT          463..484
FT                   /note="LRR 14"
FT   REPEAT          486..507
FT                   /note="LRR 15"
FT   REPEAT          509..530
FT                   /note="LRR 16"
FT   REPEAT          532..553
FT                   /note="LRR 17"
FT   REPEAT          555..576
FT                   /note="LRR 18"
FT   REPEAT          578..600
FT                   /note="LRR 19"
FT   REPEAT          602..623
FT                   /note="LRR 20"
FT   REGION          1..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  69906 MW;  2452E136BAFBBC90 CRC64;
     MNLCSSGATA SASSTSLSST GQAERNGGGK GGDGSGGGGG GGSSSNQNGS SEAINCFGGG
     PEPVSNLNST INGGGGVGGA KTNSNTTANT TATSSNSTSN GQQGHTQHNE NTATMPPETR
     PKVVTVKHPE SNKPKPTTKK SKPIQADQDV IKALQRCRDE GIKRLDLSKS SITVIPNTVK
     ECVHLTELYL YSNKIGQLPT EIGCLVNLRN LALNENSLTS LPDSLQHCNQ LKVLDLRHNK
     LAEIPPVIYR LRSLTTLYLR FNRITTVADD LRQLVNLTML SLRENKIREL GSAIGALVNL
     TTLDVSHNHL EHLPEDIGNC VNLSALDLQH NELLDIPDSI GNLKSLVRLG LRYNRLTSVP
     ASLKNCKSMD EFNVEGNGIT QLPDGMLASL NGLTIITLSR NQFTSYPTGG PAQFTNVYNI
     NLEHNRIDKI PYGIFSRAKG LTKLNMKENM LTALPLDIGT WVNMVELNLA TNALQKLPDD
     IMNLQNLEIL ILSNNMLKKI PNTIGNLRKL RILDLEENRI EVLPHEIGLL HELQRLILQT
     NQITMLPRSI GHLSQLTHLS VSENNLQFLP EEIGSLESLE NLYINQNPGL EKLPFELALC
     QNLKYLNIDK CPLSTIPPEI QAGGPSLVLQ WLKMHSPYRQ M