SUR8_DROYA
ID SUR8_DROYA Reviewed; 645 AA.
AC B4PU77;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog;
DE AltName: Full=Protein Sur-8 homolog;
DE AltName: Full=Protein soc-2 homolog;
GN Name=Sur-8; ORFNames=GE24170;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SHOC2 family. {ECO:0000305}.
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DR EMBL; CM000160; EDW97727.1; -; Genomic_DNA.
DR RefSeq; XP_002098015.2; XM_002097979.2.
DR AlphaFoldDB; B4PU77; -.
DR SMR; B4PU77; -.
DR STRING; 7245.FBpp0269180; -.
DR EnsemblMetazoa; FBtr0270688; FBpp0269180; FBgn0241301.
DR GeneID; 6537459; -.
DR KEGG; dya:Dyak_GE24170; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_23_1; -.
DR OMA; NQFTSYP; -.
DR OrthoDB; 287114at2759; -.
DR PhylomeDB; B4PU77; -.
DR ChiTaRS; Sur-8; fly.
DR Proteomes; UP000002282; Chromosome 3R.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027036; SHOC2.
DR PANTHER; PTHR48051:SF9; PTHR48051:SF9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 15.
DR PROSITE; PS51450; LRR; 18.
PE 3: Inferred from homology;
KW Leucine-rich repeat; Repeat.
FT CHAIN 1..645
FT /note="Leucine-rich repeat protein soc-2 homolog"
FT /id="PRO_0000385643"
FT REPEAT 165..186
FT /note="LRR 1"
FT REPEAT 188..209
FT /note="LRR 2"
FT REPEAT 211..232
FT /note="LRR 3"
FT REPEAT 234..255
FT /note="LRR 4"
FT REPEAT 257..278
FT /note="LRR 5"
FT REPEAT 280..301
FT /note="LRR 6"
FT REPEAT 303..324
FT /note="LRR 7"
FT REPEAT 326..347
FT /note="LRR 8"
FT REPEAT 349..371
FT /note="LRR 9"
FT REPEAT 372..393
FT /note="LRR 10"
FT REPEAT 396..417
FT /note="LRR 11"
FT REPEAT 420..441
FT /note="LRR 12"
FT REPEAT 444..465
FT /note="LRR 13"
FT REPEAT 467..488
FT /note="LRR 14"
FT REPEAT 490..511
FT /note="LRR 15"
FT REPEAT 513..534
FT /note="LRR 16"
FT REPEAT 536..557
FT /note="LRR 17"
FT REPEAT 559..580
FT /note="LRR 18"
FT REPEAT 582..604
FT /note="LRR 19"
FT REPEAT 606..627
FT /note="LRR 20"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 69717 MW; D2C727933D74368F CRC64;
MNLCSSGATA STTSLSSTGQ AERSGGVPGG GAEGGGGDGG SGNSGGGGSK TNDGSTEAPT
LCFAGGSGTA GAIVGSAELS NANSPANGAG GASGSTGSGQ QPTGSNGHSH LHNENNANMP
PETRPKMVTV KHPESNKPKP TTKKSKPIQA DQDVIKALQR CRDEGIKRLD LSKSSITVIP
STVKECVHLT ELYLYSNKIG QLPPEIGCLV SLRNLALNEN SLTSLPESLQ NCSQLKVLDL
RHNKLAEIPP VIYRLRSLTT LYLRFNRITA VADDLRQLVN LTMLSLRENK IRELGSAIGA
LVNLTTLDVS HNHLEHLPED IGNCVNLSAL DLQHNELLDI PDSIGNLKSL VRLGMRYNRL
SSVPATLKNC KSMDEFNVEG NGITQLPDGM LASLSGLTTI TLSRNQFASY PTGGPAQFTN
VYSINLEHNR IDKIPYGIFS RAKGLTKLNM KENMLTALPL DIGTWVNMVE LNLATNALQK
LPDDIMNLQN LEILILSNNM LKKIPNTIGN LRRLRILDLE ENRIEVLPHE IGLLHELQRL
ILQTNQITML PRSIGHLGNL THLSVSENNL QFLPEEIGSL ESLENLYINQ NPGLEKLPFE
LALCQNLKYL NIDKCPLSTI PPEIQAGGPS LVLQWLKMHS PYRQM
