ID   ABITM_BOVIN             Reviewed;         187 AA.
AC   Q29S16;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein Abitram {ECO:0000305};
DE   AltName: Full=Actin-binding transcription modulator;
DE   AltName: Full=Protein Simiate;
GN   Name=ABITRAM; Synonyms=FAM206A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actin-binding protein that regulates actin polymerization,
CC       filopodia dynamics and increases the branching of proximal dendrites of
CC       developing neurons. May play a role in transcription regulation.
CC       {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SUBUNIT: Interacts with F-actin (By similarity). Interacts with G-actin
CC       (By similarity). {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q80ZQ9}.
CC       Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q80ZQ9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, growth cone
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Note=Localizes to somata and dendrites
CC       in cortical neurons. Colocalizes with F- and G-actin in lamellipodia
CC       (By similarity). Colocalizes in the nucleus with PTK2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SIMILARITY: Belongs to the ABITRAM family. {ECO:0000305}.
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DR   EMBL; BC113223; AAI13224.1; -; mRNA.
DR   RefSeq; NP_001039421.1; NM_001045956.1.
DR   AlphaFoldDB; Q29S16; -.
DR   SMR; Q29S16; -.
DR   STRING; 9913.ENSBTAP00000006575; -.
DR   PaxDb; Q29S16; -.
DR   PRIDE; Q29S16; -.
DR   Ensembl; ENSBTAT00000006575; ENSBTAP00000006575; ENSBTAG00000004996.
DR   GeneID; 507081; -.
DR   KEGG; bta:507081; -.
DR   CTD; 54942; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004996; -.
DR   VGNC; VGNC:28781; ABITRAM.
DR   eggNOG; KOG3266; Eukaryota.
DR   GeneTree; ENSGT00450000040303; -.
DR   HOGENOM; CLU_107323_1_0_1; -.
DR   InParanoid; Q29S16; -.
DR   OMA; GRPCEDF; -.
DR   OrthoDB; 1277002at2759; -.
DR   TreeFam; TF313930; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000004996; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR   GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR   GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0003785; F:actin monomer binding; ISS:UniProtKB.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
DR   GO; GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB.
DR   InterPro; IPR039169; Abitram.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR13651; PTHR13651; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell projection; Nucleus; Reference proteome.
FT   CHAIN           1..187
FT                   /note="Protein Abitram"
FT                   /id="PRO_0000291927"
SQ   SEQUENCE   187 AA;  20863 MW;  22CBFD0772D9FF50 CRC64;
     MTTEPKDPVA DLAPEPAVPS LVDRYFTRWY KADVKGKPCE DHCILQHSNR ICVITLAGSH
     PVLQSGKTIK SISYQISTNC SRLQNKVSGK FKRGAQFLTE LAPLCKIYCS DGEEYTISSC
     VRGRLMEVNE NILHKPSILQ EKPSTEGYIA VVLPKFEESK SITEGLLTQK EYEEVVVKRL
     RATTAAS