ID   ABITM_DANRE             Reviewed;         177 AA.
AC   Q1LU93;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein Abitram {ECO:0000305};
DE   AltName: Full=Actin-binding transcription modulator;
DE   AltName: Full=Protein Simiate;
GN   Name=abitram; Synonyms=fam206a; ORFNames=si:ch211-254e15.2, zgc:153072;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Genes Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate actin polymerization, filopodia dynamics and
CC       arborization of neurons. {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q80ZQ9}.
CC       Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q80ZQ9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, growth cone
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Note=Localizes to somata and dendrites
CC       in cortical neurons. {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SIMILARITY: Belongs to the ABITRAM family. {ECO:0000305}.
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DR   EMBL; BX957315; CAK04782.1; -; Genomic_DNA.
DR   EMBL; BX927389; CAK04782.1; JOINED; Genomic_DNA.
DR   EMBL; BX927389; CAK05340.1; -; Genomic_DNA.
DR   EMBL; BX957315; CAK05340.1; JOINED; Genomic_DNA.
DR   EMBL; BC125852; AAI25853.1; -; mRNA.
DR   RefSeq; NP_001038394.1; NM_001044929.3.
DR   AlphaFoldDB; Q1LU93; -.
DR   SMR; Q1LU93; -.
DR   STRING; 7955.ENSDARP00000094053; -.
DR   PaxDb; Q1LU93; -.
DR   Ensembl; ENSDART00000103276; ENSDARP00000094053; ENSDARG00000070407.
DR   GeneID; 560419; -.
DR   KEGG; dre:560419; -.
DR   CTD; 54942; -.
DR   ZFIN; ZDB-GENE-060503-602; abitram.
DR   eggNOG; KOG3266; Eukaryota.
DR   GeneTree; ENSGT00450000040303; -.
DR   HOGENOM; CLU_107323_1_0_1; -.
DR   InParanoid; Q1LU93; -.
DR   OMA; GRPCEDF; -.
DR   OrthoDB; 1277002at2759; -.
DR   PhylomeDB; Q1LU93; -.
DR   TreeFam; TF313930; -.
DR   PRO; PR:Q1LU93; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000070407; Expressed in gastrula and 21 other tissues.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR   GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR   GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
DR   GO; GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB.
DR   InterPro; IPR039169; Abitram.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR13651; PTHR13651; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Nucleus; Reference proteome.
FT   CHAIN           1..177
FT                   /note="Protein Abitram"
FT                   /id="PRO_0000291932"
SQ   SEQUENCE   177 AA;  20504 MW;  3D612E464A98249F CRC64;
     MEDKEEKKAP SVIDRYFTRW YRTDLKGKPC EDHCILQHSN RICVITLAES HPIFQNGRKI
     KNINYQISDG CSRLKNKVSG KSKRGGQFLT EFAPLCRITC TDEQEFTIFS CIRGRLLEVN
     EVILNKPDLL MEKPSTEGYI AVILPKFEES KSVTEGLLTR EQYEEILTKR NQQEVPC