SURF1_DICDI
ID SURF1_DICDI Reviewed; 270 AA.
AC Q556J9; Q86K06;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=SURF1-like protein;
GN Name=surf1-1; ORFNames=DDB_G0272889;
GN and
GN Name=surf1-2; ORFNames=DDB_G0274001;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probably involved in the biogenesis of the COX complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SURF1 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70434.2; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL71082.2; -; Genomic_DNA.
DR RefSeq; XP_644359.2; XM_639267.2.
DR RefSeq; XP_645055.2; XM_639963.2.
DR AlphaFoldDB; Q556J9; -.
DR STRING; 44689.DDB0238783; -.
DR PaxDb; Q556J9; -.
DR EnsemblProtists; EAL70434; EAL70434; DDB_G0274001.
DR EnsemblProtists; EAL71082; EAL71082; DDB_G0272889.
DR GeneID; 8618730; -.
DR GeneID; 8619246; -.
DR KEGG; ddi:DDB_G0272889; -.
DR KEGG; ddi:DDB_G0274001; -.
DR dictyBase; DDB_G0272889; surf1-1.
DR dictyBase; DDB_G0274001; surf1-2.
DR eggNOG; KOG1563; Eukaryota.
DR HOGENOM; CLU_047737_4_2_1; -.
DR InParanoid; Q556J9; -.
DR OMA; WYSRDVA; -.
DR PhylomeDB; Q556J9; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q556J9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR CDD; cd06662; SURF1; 1.
DR InterPro; IPR002994; Surf1/Shy1.
DR InterPro; IPR045214; Surf1/Surf4.
DR PANTHER; PTHR23427; PTHR23427; 1.
DR Pfam; PF02104; SURF1; 1.
DR PROSITE; PS50895; SURF1; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="SURF1-like protein"
FT /id="PRO_0000344501"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..265
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 270 AA; 31623 MW; E54A3986630E483A CRC64;
MNKNKKGFKL FFIFPVIAFG LGTWQVYRYD WKKRLIQRAK DRMEEDPIEL SNSFIKNFKG
SSFGDLNKYE FRRVYLNGKV IDNQYVLLGP RSIDGTLGYY VISPLQLSDG TRILLNRGWS
ASTPKSNYKI PYAIEELKLI HQKEKEQGQQ QGNQESILYR YFNILGVISK TKERGSAFTP
TNQPEKGQWY SLDVDAMADQ LNTEPLMINT MDETEINSKP SSLPNPQFKR FDNDVESSFH
NKHMSYIGTW YTLSASLFFI YFRYMRKLPK
