SURF1_DROME
ID SURF1_DROME Reviewed; 300 AA.
AC Q9U4F3; Q8MSH4; Q9VRZ8;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=SURF1-like protein;
GN Name=Surf1; ORFNames=CG9943;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10622737; DOI=10.1016/s0014-5793(99)01571-9;
RA Poyau A., Buchet K., Godinot C.;
RT "Sequence conservation from human to prokaryotes of Surf1, a protein
RT involved in cytochrome c oxidase assembly, deficient in Leigh syndrome.";
RL FEBS Lett. 462:416-420(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-300.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16172499; DOI=10.1534/genetics.105.049072;
RA Zordan M.A., Cisotto P., Benna C., Agostino A., Rizzo G., Piccin A.,
RA Pegoraro M., Sandrelli F., Perini G., Tognon G., De Caro R., Peron S.,
RA Kronnie T.T., Megighian A., Reggiani C., Zeviani M., Costa R.;
RT "Post-transcriptional silencing and functional characterization of the
RT Drosophila melanogaster homolog of human Surf1.";
RL Genetics 172:229-241(2006).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25164807; DOI=10.1074/jbc.m114.602938;
RA Da-Re C., von Stockum S., Biscontin A., Millino C., Cisotto P.,
RA Zordan M.A., Zeviani M., Bernardi P., De Pitta C., Costa R.;
RT "Leigh syndrome in Drosophila melanogaster: morphological and biochemical
RT characterization of Surf1 post-transcriptional silencing.";
RL J. Biol. Chem. 289:29235-29246(2014).
CC -!- FUNCTION: Probably involved in the biogenesis of the COX complex.
CC {ECO:0000269|PubMed:16172499, ECO:0000269|PubMed:25164807}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P09925}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Lethal at larval stage (PubMed:16172499). Larvae
CC show reduced locomotor speed and response to light (PubMed:16172499).
CC Results in smaller muscle fibers with mitochondria defects
CC (PubMed:16172499). RNAi-mediated knockdown is lethal at larval stage
CC (PubMed:25164807). RNAi-mediated knockdown in the developing CNS, in
CC the eye and antenna disk from early larval stages shows increased
CC lifespan with reduction of COX activity, increased succinate
CC dehydrogenase (SDH) activity, reduced locomotor speed and response to
CC light (PubMed:16172499, PubMed:25164807). RNAi-mediated knockdown in
CC mesodermal derivatives from early embryonic stages to pupal
CC metamorphosis is lethal at pupal stage with muscles showing enlarged
CC and disorganized mitochondria and reduced activity of all mitochondrial
CC respiratory chain complexes (PubMed:25164807).
CC {ECO:0000269|PubMed:16172499, ECO:0000269|PubMed:25164807}.
CC -!- SIMILARITY: Belongs to the SURF1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM50675.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF182954; AAF19610.1; -; mRNA.
DR EMBL; AE014296; AAF50632.2; -; Genomic_DNA.
DR EMBL; AY118815; AAM50675.1; ALT_INIT; mRNA.
DR RefSeq; NP_524758.1; NM_080019.3.
DR AlphaFoldDB; Q9U4F3; -.
DR BioGRID; 69086; 2.
DR STRING; 7227.FBpp0076607; -.
DR PaxDb; Q9U4F3; -.
DR PRIDE; Q9U4F3; -.
DR DNASU; 44498; -.
DR EnsemblMetazoa; FBtr0076897; FBpp0076607; FBgn0029117.
DR GeneID; 44498; -.
DR KEGG; dme:Dmel_CG9943; -.
DR CTD; 6834; -.
DR FlyBase; FBgn0029117; Surf1.
DR VEuPathDB; VectorBase:FBgn0029117; -.
DR eggNOG; KOG1563; Eukaryota.
DR GeneTree; ENSGT00530000064194; -.
DR HOGENOM; CLU_047737_4_0_1; -.
DR InParanoid; Q9U4F3; -.
DR OMA; WYSRDVA; -.
DR OrthoDB; 923657at2759; -.
DR PhylomeDB; Q9U4F3; -.
DR Reactome; R-DME-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DME-611105; Respiratory electron transport.
DR Reactome; R-DME-9707564; Cytoprotection by HMOX1.
DR BioGRID-ORCS; 44498; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 44498; -.
DR PRO; PR:Q9U4F3; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0029117; Expressed in adult abdomen and 24 other tissues.
DR ExpressionAtlas; Q9U4F3; baseline and differential.
DR Genevisible; Q9U4F3; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0002168; P:instar larval development; IMP:FlyBase.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IMP:UniProtKB.
DR GO; GO:0042331; P:phototaxis; IMP:FlyBase.
DR GO; GO:0007632; P:visual behavior; IMP:FlyBase.
DR CDD; cd06662; SURF1; 1.
DR InterPro; IPR002994; Surf1/Shy1.
DR InterPro; IPR045214; Surf1/Surf4.
DR PANTHER; PTHR23427; PTHR23427; 1.
DR Pfam; PF02104; SURF1; 1.
DR PROSITE; PS50895; SURF1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..300
FT /note="SURF1-like protein"
FT /id="PRO_0000215657"
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 300 AA; 34064 MW; 59C6969FA0E9A9C1 CRC64;
MIRLGNQMCR QVAFNIQTVF RNPGTANNPR LITRKMTQQR PPVNWTTSIP NQAAKDKEKI
APLGWFLLLI PATTFGLGCW QVKRKIWKEQ LIKDLNKQLS TAPVALPDDL TDLAQMEYRL
VKIRGRFLHD KEMRLGPRSL IRPDGVETQG GLFSQRDSGN GYLIVTPFQL ADRDDIVLVN
RGWVSRKQVE PETRPLGQQQ AEVELTAVVR KGEARPQFTP DHKGNVYLYR DLARMCAATG
AAPVFLDAVY DPQTAAHAPI GGQTRVTLRN DHLSYLVTWF SLSAATSFLW YRQIVKRIPF
