ID   SURF1_RAT               Reviewed;         306 AA.
AC   Q9QXU2;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Surfeit locus protein 1;
GN   Name=Surf1; Synonyms=Surf-1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=10622737; DOI=10.1016/s0014-5793(99)01571-9;
RA   Poyau A., Buchet K., Godinot C.;
RT   "Sequence conservation from human to prokaryotes of Surf1, a protein
RT   involved in cytochrome c oxidase assembly, deficient in Leigh syndrome.";
RL   FEBS Lett. 462:416-420(1999).
CC   -!- FUNCTION: Component of the MITRAC (mitochondrial translation regulation
CC       assembly intermediate of cytochrome c oxidase complex) complex, that
CC       regulates cytochrome c oxidase assembly.
CC       {ECO:0000250|UniProtKB:Q15526}.
CC   -!- SUBUNIT: Component of the MITRAC (mitochondrial translation regulation
CC       assembly intermediate of cytochrome c oxidase complex) complex, the
CC       core components of this complex being COA3/MITRAC12 and COX14.
CC       Interacts with COA3. {ECO:0000250|UniProtKB:Q15526}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P09925}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SURF1 family. {ECO:0000305}.
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DR   EMBL; AF182952; AAF19608.1; -; mRNA.
DR   RefSeq; NP_742065.1; NM_172068.1.
DR   RefSeq; XP_006233790.1; XM_006233728.3.
DR   AlphaFoldDB; Q9QXU2; -.
DR   STRING; 10116.ENSRNOP00000057954; -.
DR   iPTMnet; Q9QXU2; -.
DR   PhosphoSitePlus; Q9QXU2; -.
DR   PaxDb; Q9QXU2; -.
DR   Ensembl; ENSRNOT00000071754; ENSRNOP00000065447; ENSRNOG00000060005.
DR   Ensembl; ENSRNOT00000118510; ENSRNOP00000092828; ENSRNOG00000005247.
DR   GeneID; 64463; -.
DR   KEGG; rno:64463; -.
DR   UCSC; RGD:620527; rat.
DR   CTD; 6834; -.
DR   RGD; 620527; Surf1.
DR   eggNOG; KOG1563; Eukaryota.
DR   eggNOG; KOG3998; Eukaryota.
DR   GeneTree; ENSGT00530000064123; -.
DR   HOGENOM; CLU_047737_4_0_1; -.
DR   InParanoid; Q9QXU2; -.
DR   OrthoDB; 923657at2759; -.
DR   PRO; PR:Q9QXU2; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000005247; Expressed in heart and 19 other tissues.
DR   Genevisible; Q9QXU2; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; ISO:RGD.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   CDD; cd06662; SURF1; 1.
DR   InterPro; IPR002994; Surf1/Shy1.
DR   InterPro; IPR045214; Surf1/Surf4.
DR   PANTHER; PTHR23427; PTHR23427; 1.
DR   Pfam; PF02104; SURF1; 1.
DR   PROSITE; PS50895; SURF1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="Surfeit locus protein 1"
FT                   /id="PRO_0000215654"
FT   TRANSMEM        68..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   306 AA;  34683 MW;  2CB7E4F5B8A94850 CRC64;
     MAAVMALTVL RSRITRWPQW ACAGPAPFCA VRRSVFGFSV RSGMVCRPHR CCSSTAETAA
     AKAEDDSFLQ WFLLFIPATA FGLGTWQVQR RKWKLKLIAE LESRVMAEPI PLPADPMELK
     NLEYRPVKVR GHFDHSKELY IMPRTMVDPV REARDAGRLS STESGAYVVT PFHCSDLGVT
     ILVNRGFVPR KKVNPETRQQ GQVLGEVDLV GIVRLTENRK PFVPENNPER SLWYYRDLDA
     MAKRTGTDPI FIDADFNSTT PGGPIGGQTR VTLRNEHMQY IITWYGLCAA TSYLWFRKFV
     RRTPGV