ID   SURF1_XENTR             Reviewed;         307 AA.
AC   A4IHH4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Surfeit locus protein 1;
GN   Name=surf1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mitochondrial respiratory chain complex IV
CC       assembly. Probably involved in the biogenesis of the COX complex.
CC       {ECO:0000250|UniProtKB:Q15526}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SURF1 family. {ECO:0000305}.
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DR   EMBL; BC135527; AAI35528.1; -; mRNA.
DR   RefSeq; NP_001016789.1; NM_001016789.2.
DR   AlphaFoldDB; A4IHH4; -.
DR   STRING; 8364.ENSXETP00000057384; -.
DR   PaxDb; A4IHH4; -.
DR   DNASU; 549543; -.
DR   GeneID; 549543; -.
DR   KEGG; xtr:549543; -.
DR   CTD; 6834; -.
DR   Xenbase; XB-GENE-6453389; surf1.
DR   eggNOG; KOG1563; Eukaryota.
DR   InParanoid; A4IHH4; -.
DR   OrthoDB; 923657at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   CDD; cd06662; SURF1; 1.
DR   InterPro; IPR002994; Surf1/Shy1.
DR   InterPro; IPR045214; Surf1/Surf4.
DR   PANTHER; PTHR23427; PTHR23427; 1.
DR   Pfam; PF02104; SURF1; 1.
DR   PROSITE; PS50895; SURF1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Surfeit locus protein 1"
FT                   /id="PRO_0000344497"
FT   TRANSMEM        69..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  34436 MW;  521B5FAE43372866 CRC64;
     MALPGVTKLL LLPGVRAQLL NTPVRLSHWA TPGRCTKSCH AYLQKNLRFC TTRSFSSVSP
     AAESSEDTVL KWLLLLIPVA TFSLGTWQVQ RRSWKLKLIQ EMEARVSGKP IPLTTDPMEI
     KELEYRPVKV RGHFDHSKEL YILPRTLVDP EREAREAGQL ASNTQSGAQV ITPFYCSDLG
     ITILVNRGFV PKKKVNPETR PKGQVSGEVE LVGIVRLNET RKPFVPHNDP SRNLWHYKDL
     SAMAQVVGAE PILIDADRGS TVPGGPIGGQ TRVTLRNEHM QYIVTWYGLC AATTYLWCKK
     FIRKVAL