SURF2_HUMAN
ID SURF2_HUMAN Reviewed; 256 AA.
AC Q15527; Q6IBP9; Q96CD1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 4.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Surfeit locus protein 2;
DE Short=Surf-2;
GN Name=SURF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLN-221.
RX PubMed=7702754; DOI=10.1089/dna.1994.13.1117;
RA Lennard A., Gaston K., Fried M.;
RT "The Surf-1 and Surf-2 genes and their essential bidirectional promoter
RT elements are conserved between mouse and human.";
RL DNA Cell Biol. 13:1117-1126(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-213.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SIMILARITY: Belongs to the SURF2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z35094; CAA84477.1; -; mRNA.
DR EMBL; CR456753; CAG33034.1; -; mRNA.
DR EMBL; AL158826; CAI12838.1; -; Genomic_DNA.
DR EMBL; BC014411; AAH14411.1; -; mRNA.
DR CCDS; CCDS6967.1; -.
DR PIR; S57747; S57747.
DR RefSeq; NP_001265857.1; NM_001278928.1.
DR RefSeq; NP_059973.4; NM_017503.4.
DR AlphaFoldDB; Q15527; -.
DR BioGRID; 112702; 63.
DR IntAct; Q15527; 25.
DR MINT; Q15527; -.
DR STRING; 9606.ENSP00000361032; -.
DR iPTMnet; Q15527; -.
DR PhosphoSitePlus; Q15527; -.
DR BioMuta; SURF2; -.
DR DMDM; 317373505; -.
DR EPD; Q15527; -.
DR jPOST; Q15527; -.
DR MassIVE; Q15527; -.
DR MaxQB; Q15527; -.
DR PaxDb; Q15527; -.
DR PeptideAtlas; Q15527; -.
DR PRIDE; Q15527; -.
DR ProteomicsDB; 60618; -.
DR Antibodypedia; 31850; 47 antibodies from 17 providers.
DR DNASU; 6835; -.
DR Ensembl; ENST00000371964.5; ENSP00000361032.4; ENSG00000148291.10.
DR Ensembl; ENST00000630633.2; ENSP00000487370.1; ENSG00000281024.3.
DR GeneID; 6835; -.
DR KEGG; hsa:6835; -.
DR MANE-Select; ENST00000371964.5; ENSP00000361032.4; NM_017503.5; NP_059973.4.
DR UCSC; uc004cdi.4; human.
DR CTD; 6835; -.
DR DisGeNET; 6835; -.
DR GeneCards; SURF2; -.
DR HGNC; HGNC:11475; SURF2.
DR HPA; ENSG00000148291; Tissue enhanced (testis).
DR MIM; 185630; gene.
DR neXtProt; NX_Q15527; -.
DR OpenTargets; ENSG00000148291; -.
DR PharmGKB; PA36260; -.
DR VEuPathDB; HostDB:ENSG00000148291; -.
DR eggNOG; ENOG502RYGJ; Eukaryota.
DR GeneTree; ENSGT00390000016800; -.
DR HOGENOM; CLU_094630_1_0_1; -.
DR InParanoid; Q15527; -.
DR OrthoDB; 1602731at2759; -.
DR PhylomeDB; Q15527; -.
DR TreeFam; TF329107; -.
DR PathwayCommons; Q15527; -.
DR SignaLink; Q15527; -.
DR BioGRID-ORCS; 6835; 13 hits in 1081 CRISPR screens.
DR ChiTaRS; SURF2; human.
DR GenomeRNAi; 6835; -.
DR Pharos; Q15527; Tdark.
DR PRO; PR:Q15527; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q15527; protein.
DR Bgee; ENSG00000148291; Expressed in left testis and 99 other tissues.
DR Genevisible; Q15527; HS.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR008833; Surf2.
DR Pfam; PF05477; SURF2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..256
FT /note="Surfeit locus protein 2"
FT /id="PRO_0000072319"
FT REGION 133..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..249
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 190
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 195
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT VARIANT 213
FT /note="G -> S (in dbSNP:rs12763)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_014785"
FT VARIANT 221
FT /note="R -> Q (in dbSNP:rs7863933)"
FT /evidence="ECO:0000269|PubMed:7702754"
FT /id="VAR_057001"
FT CONFLICT 24
FT /note="A -> T (in Ref. 1; CAA84477)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="P -> T (in Ref. 1; CAA84477)"
FT /evidence="ECO:0000305"
FT CONFLICT 142..143
FT /note="DG -> EA (in Ref. 1; CAA84477)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="G -> A (in Ref. 1; CAA84477)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 29618 MW; 5CA1BDFB228E5527 CRC64;
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP
AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG
VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD
LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DEGRRETTVY RGLVQKRGKK QLGSLKKKFK
SHHRKPKSFS SCKQPG
