SURF2_MOUSE
ID SURF2_MOUSE Reviewed; 257 AA.
AC P09926;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Surfeit locus protein 2;
DE Short=Surf-2;
GN Name=Surf2; Synonyms=Surf-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3025660; DOI=10.1128/mcb.6.12.4558-4569.1986;
RA Williams T.J., Fried M.;
RT "The MES-1 murine enhancer element is closely associated with the
RT heterogeneous 5' ends of two divergent transcription units.";
RL Mol. Cell. Biol. 6:4558-4569(1986).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SURF2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M14689; AAA40154.1; -; Genomic_DNA.
DR CCDS; CCDS15816.1; -.
DR PIR; A25394; A25394.
DR RefSeq; NP_038706.1; NM_013678.2.
DR AlphaFoldDB; P09926; -.
DR STRING; 10090.ENSMUSP00000015017; -.
DR iPTMnet; P09926; -.
DR PhosphoSitePlus; P09926; -.
DR EPD; P09926; -.
DR PaxDb; P09926; -.
DR PeptideAtlas; P09926; -.
DR PRIDE; P09926; -.
DR ProteomicsDB; 254498; -.
DR Antibodypedia; 31850; 47 antibodies from 17 providers.
DR DNASU; 20931; -.
DR Ensembl; ENSMUST00000015017; ENSMUSP00000015017; ENSMUSG00000014873.
DR GeneID; 20931; -.
DR KEGG; mmu:20931; -.
DR UCSC; uc008iwj.1; mouse.
DR CTD; 6835; -.
DR MGI; MGI:98444; Surf2.
DR VEuPathDB; HostDB:ENSMUSG00000014873; -.
DR eggNOG; ENOG502QW1X; Eukaryota.
DR GeneTree; ENSGT00390000016800; -.
DR HOGENOM; CLU_094630_1_0_1; -.
DR InParanoid; P09926; -.
DR OMA; GHEFPCN; -.
DR OrthoDB; 1602731at2759; -.
DR PhylomeDB; P09926; -.
DR TreeFam; TF329107; -.
DR BioGRID-ORCS; 20931; 0 hits in 60 CRISPR screens.
DR ChiTaRS; Surf2; mouse.
DR PRO; PR:P09926; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P09926; protein.
DR Bgee; ENSMUSG00000014873; Expressed in ileal epithelium and 263 other tissues.
DR ExpressionAtlas; P09926; baseline and differential.
DR Genevisible; P09926; MM.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR InterPro; IPR008833; Surf2.
DR Pfam; PF05477; SURF2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..257
FT /note="Surfeit locus protein 2"
FT /id="PRO_0000072320"
FT REGION 134..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..247
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 196
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q15527"
SQ SEQUENCE 257 AA; 30355 MW; 9DF3F33FF19F2BC5 CRC64;
MDEPPSDVLA FLRQHPSLRL LPNTRKVRCS LTGHELPCRL PELQEYTRGK KYQRLSSSFS
NFDYAAFEPH IVPSTKNRHQ LFCKLTLRHI NKSPEHVLRH TQGRRYQRAL HQYEECQKQG
VEYVPACLLH KRKKREDQTN SDELPGQRTG FWEPASSDEE DALSDDSMTD LYPPELFTKR
ELGKPKNDDT PEDFLTDQQD EKPEHSEEKS FREREEARVG HKRGRKLRKK QLTSLTKKFK
SYHHKPKNFS SFKQLGR
