SURF4_BOVIN
ID SURF4_BOVIN Reviewed; 269 AA.
AC A7YY49;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Surfeit locus protein 4 {ECO:0000305};
GN Name=SURF4 {ECO:0000250|UniProtKB:O15260};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export
CC of lipoproteins by recruiting cargos into COPII vesicles to facilitate
CC their secretion. Acts as a cargo receptor for lipoproteins bearing both
CC APOB and APOA1, thereby regulating lipoprotein delivery and the
CC maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to
CC mediate transport of circulating lipoproteins. Promotes the secretion
CC of PCSK9. Also mediates the efficient secretion of erythropoietin
CC (EPO). May also play a role in the maintenance of the architecture of
CC the endoplasmic reticulum-Golgi intermediate compartment and of the
CC Golgi. {ECO:0000250|UniProtKB:O15260}.
CC -!- SUBUNIT: Found in a complex composed at least of SURF4, TMED2 and
CC TMED10. May interact with LMAN1 (By similarity). Interacts with ZFYVE27
CC and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts
CC with STING1. Interacts with SAR1B. Interacts with TMEM41B (By
CC similarity). {ECO:0000250|UniProtKB:O15260,
CC ECO:0000250|UniProtKB:Q64310}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260};
CC Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the
CC endoplasmic reticulum and the Golgi. {ECO:0000250|UniProtKB:O15260}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250|UniProtKB:O15260}.
CC -!- SIMILARITY: Belongs to the SURF4 family. {ECO:0000305}.
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DR EMBL; BC151306; AAI51307.1; -; mRNA.
DR RefSeq; NP_001095979.1; NM_001102509.1.
DR AlphaFoldDB; A7YY49; -.
DR PeptideAtlas; A7YY49; -.
DR PRIDE; A7YY49; -.
DR Ensembl; ENSBTAT00000072528; ENSBTAP00000066752; ENSBTAG00000051352.
DR GeneID; 526045; -.
DR KEGG; bta:526045; -.
DR CTD; 6836; -.
DR VEuPathDB; HostDB:ENSBTAG00000051352; -.
DR VGNC; VGNC:106962; SURF4.
DR GeneTree; ENSGT00530000064123; -.
DR InParanoid; A7YY49; -.
DR OMA; RHRHFPW; -.
DR OrthoDB; 1272733at2759; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000051352; Expressed in saliva-secreting gland and 108 other tissues.
DR ExpressionAtlas; A7YY49; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0038024; F:cargo receptor activity; ISS:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR GO; GO:0042953; P:lipoprotein transport; ISS:UniProtKB.
DR GO; GO:0010638; P:positive regulation of organelle organization; IEA:Ensembl.
DR GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR InterPro; IPR045214; Surf1/Surf4.
DR InterPro; IPR002995; Surf4.
DR PANTHER; PTHR23427; PTHR23427; 1.
DR Pfam; PF02077; SURF4; 1.
DR PROSITE; PS01339; SURF4; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..269
FT /note="Surfeit locus protein 4"
FT /id="PRO_0000350581"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 266..269
FT /note="Di-lysine motif"
FT /evidence="ECO:0000250|UniProtKB:O15260"
SQ SEQUENCE 269 AA; 30422 MW; 2907C6AFBD2605F2 CRC64;
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN
CGYLLASSFV FLNLLGQLTG CILVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN
LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF
SILQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF
QTMSVIGGLL LVVALGPGGV SMDEKKKEW
