ID   SURF4_DANRE             Reviewed;         269 AA.
AC   Q7SZQ7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Surfeit locus protein 4 {ECO:0000305};
GN   Name=surf4 {ECO:0000250|UniProtKB:O15260};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export
CC       of lipoproteins by recruiting cargos into COPII vesicles to facilitate
CC       their secretion. Acts as a cargo receptor for lipoproteins bearing both
CC       APOB and APOA1, thereby regulating lipoprotein delivery and the
CC       maintenance of lipid homeostasis. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC       membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the
CC       endoplasmic reticulum and the Golgi. {ECO:0000250|UniProtKB:O15260}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SIMILARITY: Belongs to the SURF4 family. {ECO:0000305}.
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DR   EMBL; BC056295; AAH56295.1; -; mRNA.
DR   EMBL; BC066509; AAH66509.1; -; mRNA.
DR   RefSeq; NP_957421.1; NM_201127.1.
DR   AlphaFoldDB; Q7SZQ7; -.
DR   STRING; 7955.ENSDARP00000088722; -.
DR   PaxDb; Q7SZQ7; -.
DR   Ensembl; ENSDART00000172177; ENSDARP00000132774; ENSDARG00000104647.
DR   GeneID; 394102; -.
DR   KEGG; dre:394102; -.
DR   CTD; 6836; -.
DR   ZFIN; ZDB-GENE-040426-1426; surf4.
DR   eggNOG; KOG3998; Eukaryota.
DR   GeneTree; ENSGT00530000064123; -.
DR   HOGENOM; CLU_056195_0_0_1; -.
DR   InParanoid; Q7SZQ7; -.
DR   OMA; RHRHFPW; -.
DR   OrthoDB; 1272733at2759; -.
DR   PhylomeDB; Q7SZQ7; -.
DR   TreeFam; TF300001; -.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   Reactome; R-DRE-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q7SZQ7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000104647; Expressed in muscle tissue and 23 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038024; F:cargo receptor activity; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR   GO; GO:0042953; P:lipoprotein transport; ISS:UniProtKB.
DR   GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR   InterPro; IPR045214; Surf1/Surf4.
DR   InterPro; IPR002995; Surf4.
DR   PANTHER; PTHR23427; PTHR23427; 1.
DR   Pfam; PF02077; SURF4; 1.
DR   PROSITE; PS01339; SURF4; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..269
FT                   /note="Surfeit locus protein 4"
FT                   /id="PRO_0000350582"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           266..269
FT                   /note="Di-lysine motif"
FT                   /evidence="ECO:0000250|UniProtKB:O15260"
SQ   SEQUENCE   269 AA;  30191 MW;  03387864C3EDD18C CRC64;
     MGQEDMMSAA EDLADQFLRV TKQYLPHMAR LCLISTFLED GIRMWFQWSE QRDYIEATWS
     CGYFLATCFV IINLIGQIGG CVLVLSRNLV QYACFGLFCI IALQTVAYSI LWDLKFLMRN
     LALGGGLLLL LAESRSEGKS MFAGVPSMGE SSPKQYMQLG GRVLLVLMFM TLLHFDSDFF
     SILQNMVGTA LIILVAVGFK TKLAALTLVV WLLAINVYFN AFWTVPAYKP MHDFLKYDFF
     QTTSVIGGLL LVVALGPGGV SMDEKKKEW