ID   SURF4_PONAB             Reviewed;         269 AA.
AC   Q5R705;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Surfeit locus protein 4 {ECO:0000305};
GN   Name=SURF4 {ECO:0000250|UniProtKB:O15260};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export
CC       of lipoproteins by recruiting cargos into COPII vesicles to facilitate
CC       their secretion. Acts as a cargo receptor for lipoproteins bearing both
CC       APOB and APOA1, thereby regulating lipoprotein delivery and the
CC       maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to
CC       mediate transport of circulating lipoproteins. Promotes the secretion
CC       of PCSK9. Also mediates the efficient secretion of erythropoietin
CC       (EPO). May also play a role in the maintenance of the architecture of
CC       the endoplasmic reticulum-Golgi intermediate compartment and of the
CC       Golgi. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SUBUNIT: Found in a complex composed at least of SURF4, TMED2 and
CC       TMED10. May interact with LMAN1 (By similarity). Interacts with ZFYVE27
CC       and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts
CC       with STING1. Interacts with SAR1B. Interacts with TMEM41B (By
CC       similarity). {ECO:0000250|UniProtKB:O15260,
CC       ECO:0000250|UniProtKB:Q64310}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC       membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the
CC       endoplasmic reticulum and the Golgi. {ECO:0000250|UniProtKB:O15260}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SIMILARITY: Belongs to the SURF4 family. {ECO:0000305}.
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DR   EMBL; CR860318; CAH92455.1; -; mRNA.
DR   RefSeq; NP_001126447.1; NM_001132975.1.
DR   AlphaFoldDB; Q5R705; -.
DR   STRING; 9601.ENSPPYP00000022130; -.
DR   Ensembl; ENSPPYT00000057041; ENSPPYP00000026839; ENSPPYG00000019733.
DR   GeneID; 100173432; -.
DR   KEGG; pon:100173432; -.
DR   CTD; 6836; -.
DR   eggNOG; KOG3998; Eukaryota.
DR   GeneTree; ENSGT00530000064123; -.
DR   HOGENOM; CLU_056195_0_0_1; -.
DR   InParanoid; Q5R705; -.
DR   OrthoDB; 1272733at2759; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0038024; F:cargo receptor activity; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR   GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR   GO; GO:0042953; P:lipoprotein transport; ISS:UniProtKB.
DR   GO; GO:0010638; P:positive regulation of organelle organization; IEA:Ensembl.
DR   GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR   InterPro; IPR045214; Surf1/Surf4.
DR   InterPro; IPR002995; Surf4.
DR   PANTHER; PTHR23427; PTHR23427; 1.
DR   Pfam; PF02077; SURF4; 1.
DR   PROSITE; PS01339; SURF4; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..269
FT                   /note="Surfeit locus protein 4"
FT                   /id="PRO_0000290004"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           266..269
FT                   /note="Di-lysine motif"
FT                   /evidence="ECO:0000250|UniProtKB:O15260"
SQ   SEQUENCE   269 AA;  30394 MW;  03366E29882B97A5 CRC64;
     MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN
     CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN
     LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF
     SIVQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF
     QTMSVIGGLL LVVALGPGGV SMDEKKKEW