SURF4_SCHPO
ID SURF4_SCHPO Reviewed; 302 AA.
AC O74559;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Surfeit locus protein 4 homolog;
GN ORFNames=SPCC970.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P53337}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250|UniProtKB:O15260}.
CC -!- SIMILARITY: Belongs to the SURF4 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20699.1; -; Genomic_DNA.
DR PIR; T41674; T41674.
DR RefSeq; NP_587849.1; NM_001022842.2.
DR AlphaFoldDB; O74559; -.
DR BioGRID; 276078; 5.
DR STRING; 4896.SPCC970.06.1; -.
DR iPTMnet; O74559; -.
DR PaxDb; O74559; -.
DR EnsemblFungi; SPCC970.06.1; SPCC970.06.1:pep; SPCC970.06.
DR GeneID; 2539516; -.
DR KEGG; spo:SPCC970.06; -.
DR PomBase; SPCC970.06; -.
DR VEuPathDB; FungiDB:SPCC970.06; -.
DR eggNOG; KOG3998; Eukaryota.
DR HOGENOM; CLU_056195_0_0_1; -.
DR InParanoid; O74559; -.
DR OMA; RHRHFPW; -.
DR PhylomeDB; O74559; -.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:O74559; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; ISO:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:PomBase.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0097020; F:COPII receptor activity; ISO:PomBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR045214; Surf1/Surf4.
DR InterPro; IPR002995; Surf4.
DR PANTHER; PTHR23427; PTHR23427; 1.
DR Pfam; PF02077; SURF4; 1.
DR PROSITE; PS01339; SURF4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..302
FT /note="Surfeit locus protein 4 homolog"
FT /id="PRO_0000127670"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 299..302
FT /note="Di-lysine motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 302 AA; 34386 MW; 954C02D206DA03D4 CRC64;
MTSRSPFSTI PLSMNQDSYQ TRTTVGIRKK TFSERACQFM EQAETFMAPF TPYMPLLGRF
LIVATYFEDA IRIVTQWPEQ VSYMRDYRRF RFGTAPLLLF VCVVLMLVGS TLVVFKKRQA
YAIGSLLFVT LLQAFAYGLI TSGEMFFRNM SVIGGLCLVA SDTFIHRRIN RFAGLPAVSE
HNKRTYFQLA GRVLLIFMFL GLLAKEGSGI SWTRILVHIL SVTACAMVVI GFKAKFFAAV
LVLILSVANF IINSFWSVPR ESPYRDFYRY DFFQTLSIVG GLLYLVNTGP GKFSVDEKKK
IY
