ID   SURF4_TAKRU             Reviewed;         269 AA.
AC   O57590;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Surfeit locus protein 4 {ECO:0000305};
GN   Name=surf4 {ECO:0000303|PubMed:9414319};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9414319; DOI=10.1101/gr.7.12.1138;
RA   Armes N., Gilley J., Fried M.;
RT   "The comparative genomic structure and sequence of the surfeit gene
RT   homologs in the puffer fish Fugu rubripes and their association with CpG-
RT   rich islands.";
RL   Genome Res. 7:1138-1152(1997).
CC   -!- FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export
CC       of lipoproteins by recruiting cargos into COPII vesicles to facilitate
CC       their secretion. Acts as a cargo receptor for lipoproteins bearing both
CC       APOB and APOA1, thereby regulating lipoprotein delivery and the
CC       maintenance of lipid homeostasis. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC       membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the
CC       endoplasmic reticulum and the Golgi. {ECO:0000250|UniProtKB:O15260}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250|UniProtKB:O15260}.
CC   -!- SIMILARITY: Belongs to the SURF4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y15170; CAA75441.1; -; Genomic_DNA.
DR   RefSeq; XP_003965425.1; XM_003965376.2.
DR   AlphaFoldDB; O57590; -.
DR   STRING; 31033.ENSTRUP00000047790; -.
DR   GeneID; 101075587; -.
DR   KEGG; tru:101075587; -.
DR   CTD; 6836; -.
DR   eggNOG; KOG3998; Eukaryota.
DR   HOGENOM; CLU_056195_0_0_1; -.
DR   InParanoid; O57590; -.
DR   OMA; RHRHFPW; -.
DR   OrthoDB; 1272733at2759; -.
DR   TreeFam; TF300001; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038024; F:cargo receptor activity; ISS:UniProtKB.
DR   GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR   GO; GO:0042953; P:lipoprotein transport; ISS:UniProtKB.
DR   GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR   InterPro; IPR045214; Surf1/Surf4.
DR   InterPro; IPR002995; Surf4.
DR   PANTHER; PTHR23427; PTHR23427; 1.
DR   Pfam; PF02077; SURF4; 1.
DR   PROSITE; PS01339; SURF4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..269
FT                   /note="Surfeit locus protein 4"
FT                   /id="PRO_0000127666"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           266..269
FT                   /note="Di-lysine motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   269 AA;  30393 MW;  0271107917A4610B CRC64;
     MGQEDLMNRA EDVADQFLRV TKQYLPHLAR LCLISTFLED GIRMWFQWNE QRDYIEATWS
     CGYFLATCFV LLNLIGQLGG CVLILSRNFV QYACFGLFGI IALQTVAYSI LWDLKFLMRN
     LALGGGLLLL LAESRSEGKS MFAGVPSMGE SSPKQYMQLG GRVLLVLMFM TLLHFDFNFF
     SILQNLVGTA LIILVAIGFK TKLAALTLVL WLLVINVYFN AFWTIPAYKP MHDFLKYDFF
     QTTSVIGGLL LVVALGPGGV SMDEKKKEW