ID   SURF6_BOVIN             Reviewed;         353 AA.
AC   Q0VCY3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Surfeit locus protein 6;
GN   Name=SURF6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to both DNA and RNA in vitro, with a stronger binding
CC       capacity for RNA. May represent a nucleolar constitutive protein
CC       involved in ribosomal biosynthesis or assembly (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus,
CC       nucleolus {ECO:0000250}. Note=Granular component of the nucleolus.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SURF6 family. {ECO:0000305}.
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DR   EMBL; BC119935; AAI19936.1; -; mRNA.
DR   RefSeq; NP_001068997.1; NM_001075529.1.
DR   AlphaFoldDB; Q0VCY3; -.
DR   SMR; Q0VCY3; -.
DR   STRING; 9913.ENSBTAP00000015353; -.
DR   PaxDb; Q0VCY3; -.
DR   PeptideAtlas; Q0VCY3; -.
DR   PRIDE; Q0VCY3; -.
DR   Ensembl; ENSBTAT00000015353; ENSBTAP00000015353; ENSBTAG00000011554.
DR   GeneID; 511610; -.
DR   KEGG; bta:511610; -.
DR   CTD; 6838; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011554; -.
DR   VGNC; VGNC:35485; SURF6.
DR   eggNOG; KOG2885; Eukaryota.
DR   GeneTree; ENSGT00390000006980; -.
DR   HOGENOM; CLU_067122_0_0_1; -.
DR   InParanoid; Q0VCY3; -.
DR   OMA; QKKRTDN; -.
DR   OrthoDB; 1153190at2759; -.
DR   TreeFam; TF321608; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000011554; Expressed in esophagus and 107 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0001652; C:granular component; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR029190; Rrp14/SURF6_C.
DR   InterPro; IPR007019; SURF6.
DR   PANTHER; PTHR14369; PTHR14369; 1.
DR   Pfam; PF04935; SURF6; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT   CHAIN           1..353
FT                   /note="Surfeit locus protein 6"
FT                   /id="PRO_0000284061"
FT   REGION          19..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          121..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           45..49
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           149..153
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        46..60
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..159
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..317
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..335
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         133
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75683"
FT   MOD_RES         221
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O75683"
SQ   SEQUENCE   353 AA;  40642 MW;  0B099D1444C51046 CRC64;
     MTSLLAKDAY LQGLAKKICS QPSAEPQKRK SAGKTQVSEA AAPPRKKRKK AQKKSRERER
     KTAKPKAQAS AEKSEARKPE VAKEEEGATS STRVPADGLA AEPDSLFALD VLRQRLHEKI
     QEARGQGSAK ELSAAVLEKR RRRKQERDRK KRKRRELRAK EKAAKALEGA EATEPDLQVP
     REEAQAQPGL LFNKVEVTEE EPANKAQRRK EKRQKLKGNL TPLTGRNYRQ LLERLQARQA
     RLEDLRDRDA GQAQELEAKM RWTNLLYKAE GVRIRDDERL LQEALKRKEK RRAQRQRAWE
     KRTAHVVGKM QQRQDQRRQN LRKKKAAKAE RRLEKARKKG RILPQDLERA GLA