SURF6_HUMAN
ID SURF6_HUMAN Reviewed; 361 AA.
AC O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Surfeit locus protein 6;
GN Name=SURF6; Synonyms=SURF-6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10675619; DOI=10.1016/s0378-1119(99)00551-x;
RA Magoulas C., Fried M.;
RT "Isolation and genomic analysis of the human surf-6 gene: a member of the
RT Surfeit locus.";
RL Gene 243:115-123(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
RX PubMed=11891058; DOI=10.1016/s0378-1119(02)00379-7;
RA Angiolillo A., Russo G., Porcellini A., Smaldone S., D'Alessandro F.,
RA Pietropaolo C.;
RT "The human homologue of the mouse Surf5 gene encodes multiple alternatively
RT spliced transcripts.";
RL Gene 284:169-178(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17924679; DOI=10.1021/pr070152u;
RA Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
RT "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells
RT and high confident phosphopeptide identification by cross-validation of
RT MS/MS and MS/MS/MS spectra.";
RL J. Proteome Res. 6:4150-4162(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND SER-138, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74 AND THR-229, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74; SER-138 AND THR-229, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Binds to both DNA and RNA in vitro, with a stronger binding
CC capacity for RNA. May represent a nucleolar constitutive protein
CC involved in ribosomal biosynthesis or assembly (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC O75683; P68400: CSNK2A1; NbExp=2; IntAct=EBI-2691252, EBI-347804;
CC O75683; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-2691252, EBI-10175124;
CC O75683; P35268: RPL22; NbExp=3; IntAct=EBI-2691252, EBI-354533;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus,
CC nucleolus {ECO:0000250}. Note=Granular component of the nucleolus.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SURF6 family. {ECO:0000305}.
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DR EMBL; AF186772; AAD56587.1; -; Genomic_DNA.
DR EMBL; AL158826; CAI12825.1; -; Genomic_DNA.
DR EMBL; CH471090; EAW88055.1; -; Genomic_DNA.
DR EMBL; BC003001; AAH03001.1; -; mRNA.
DR EMBL; BC006197; AAH06197.1; -; mRNA.
DR EMBL; BC014878; AAH14878.1; -; mRNA.
DR EMBL; AJ224639; CAA12054.1; -; Genomic_DNA.
DR CCDS; CCDS6962.1; -.
DR RefSeq; NP_001265871.1; NM_001278942.1.
DR RefSeq; NP_006744.2; NM_006753.5.
DR AlphaFoldDB; O75683; -.
DR SMR; O75683; -.
DR BioGRID; 112705; 412.
DR IntAct; O75683; 61.
DR STRING; 9606.ENSP00000361092; -.
DR iPTMnet; O75683; -.
DR PhosphoSitePlus; O75683; -.
DR SwissPalm; O75683; -.
DR BioMuta; SURF6; -.
DR EPD; O75683; -.
DR jPOST; O75683; -.
DR MassIVE; O75683; -.
DR MaxQB; O75683; -.
DR PaxDb; O75683; -.
DR PeptideAtlas; O75683; -.
DR PRIDE; O75683; -.
DR ProteomicsDB; 50156; -.
DR Antibodypedia; 18324; 114 antibodies from 18 providers.
DR DNASU; 6838; -.
DR Ensembl; ENST00000372022.6; ENSP00000361092.4; ENSG00000148296.7.
DR Ensembl; ENST00000629980.2; ENSP00000485909.1; ENSG00000281309.2.
DR GeneID; 6838; -.
DR KEGG; hsa:6838; -.
DR MANE-Select; ENST00000372022.6; ENSP00000361092.4; NM_006753.6; NP_006744.2.
DR UCSC; uc004cdb.6; human.
DR CTD; 6838; -.
DR DisGeNET; 6838; -.
DR GeneCards; SURF6; -.
DR HGNC; HGNC:11478; SURF6.
DR HPA; ENSG00000148296; Low tissue specificity.
DR MIM; 185642; gene.
DR neXtProt; NX_O75683; -.
DR OpenTargets; ENSG00000148296; -.
DR PharmGKB; PA36263; -.
DR VEuPathDB; HostDB:ENSG00000148296; -.
DR eggNOG; KOG2885; Eukaryota.
DR GeneTree; ENSGT00390000006980; -.
DR HOGENOM; CLU_067122_0_0_1; -.
DR InParanoid; O75683; -.
DR OMA; QKKRTDN; -.
DR OrthoDB; 1153190at2759; -.
DR PhylomeDB; O75683; -.
DR TreeFam; TF321608; -.
DR PathwayCommons; O75683; -.
DR SignaLink; O75683; -.
DR BioGRID-ORCS; 6838; 467 hits in 1084 CRISPR screens.
DR ChiTaRS; SURF6; human.
DR GeneWiki; SURF6; -.
DR GenomeRNAi; 6838; -.
DR Pharos; O75683; Tbio.
DR PRO; PR:O75683; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; O75683; protein.
DR Bgee; ENSG00000148296; Expressed in sural nerve and 96 other tissues.
DR Genevisible; O75683; HS.
DR GO; GO:0005694; C:chromosome; IDA:HPA.
DR GO; GO:0001652; C:granular component; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR DisProt; DP02009; -.
DR InterPro; IPR029190; Rrp14/SURF6_C.
DR InterPro; IPR007019; SURF6.
DR PANTHER; PTHR14369; PTHR14369; 1.
DR Pfam; PF04935; SURF6; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..361
FT /note="Surfeit locus protein 6"
FT /id="PRO_0000220969"
FT REGION 20..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..49
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 154..158
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 20..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..164
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17924679,
FT ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 229
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VARIANT 163
FT /note="R -> W (in dbSNP:rs886090)"
FT /id="VAR_014532"
FT VARIANT 175
FT /note="T -> M (in dbSNP:rs886089)"
FT /id="VAR_014533"
FT VARIANT 193
FT /note="R -> Q (in dbSNP:rs34657219)"
FT /id="VAR_052199"
FT VARIANT 201
FT /note="N -> H (in dbSNP:rs35316446)"
FT /id="VAR_052200"
FT VARIANT 311
FT /note="T -> M (in dbSNP:rs1800867)"
FT /id="VAR_014534"
FT CONFLICT 6
FT /note="A -> T (in Ref. 5; CAA12054)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="D -> N (in Ref. 1; AAD56587)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 41450 MW; 34F63992E3E82797 CRC64;
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE
KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR
LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV
VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL
ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL
V
