SUS1_CANAL
ID SUS1_CANAL Reviewed; 119 AA.
AC Q5ADP6; A0A1D8PKT8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Transcription and mRNA export factor SUS1 {ECO:0000255|HAMAP-Rule:MF_03046};
GN Name=SUS1 {ECO:0000255|HAMAP-Rule:MF_03046};
GN OrderedLocusNames=CAALFM_C307050WA; ORFNames=CaO19.14087, CaO19.6795;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC association with both the TREX-2 and the SAGA complexes. At the
CC promoters, SAGA is required for recruitment of the basal transcription
CC machinery. It influences RNA polymerase II transcriptional activity
CC through different activities such as TBP interaction and promoter
CC selectivity, interaction with transcription activators, and chromatin
CC modification through histone acetylation and deubiquitination. Within
CC the SAGA complex, participates in a subcomplex required for
CC deubiquitination of H2B and for the maintenance of steady-state H3
CC methylation levels. The TREX-2 complex functions in docking export-
CC competent ribonucleoprotein particles (mRNPs) to the nuclear entrance
CC of the nuclear pore complex (nuclear basket). TREX-2 participates in
CC mRNA export and accurate chromatin positioning in the nucleus by
CC tethering genes to the nuclear periphery. May also be involved in
CC cytoplasmic mRNA decay by interaction with components of P-bodies (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC complex (transcription and export complex 2), composed of at least
CC SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The
CC TREX-2 complex interacts with the nucleoporin NUP1. Component of the
CC 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5
CC distinct domains with specialized functions. Within the SAGA complex,
CC SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA
CC called the DUB module (deubiquitination module). Interacts directly
CC with THP1, SAC3, SGF11, and with the RNA polymerase II.
CC {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC Rule:MF_03046}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03046}.
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DR EMBL; CP017625; AOW28708.1; -; Genomic_DNA.
DR RefSeq; XP_719891.1; XM_714798.1.
DR AlphaFoldDB; Q5ADP6; -.
DR SMR; Q5ADP6; -.
DR STRING; 237561.Q5ADP6; -.
DR GeneID; 3638515; -.
DR KEGG; cal:CAALFM_C307050WA; -.
DR CGD; CAL0000178918; orf19.14087.
DR VEuPathDB; FungiDB:C3_07050W_A; -.
DR eggNOG; ENOG502S9WJ; Eukaryota.
DR HOGENOM; CLU_134052_2_1_1; -.
DR InParanoid; Q5ADP6; -.
DR OMA; YESGWFD; -.
DR OrthoDB; 1538551at2759; -.
DR PHI-base; PHI:8892; -.
DR PRO; PR:Q5ADP6; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0071819; C:DUBm complex; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; PTHR12514; 1.
DR Pfam; PF10163; EnY2; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; Cytoplasm; mRNA transport; Nucleus;
KW Protein transport; Reference proteome; Transcription;
KW Transcription regulation; Translocation; Transport.
FT CHAIN 1..119
FT /note="Transcription and mRNA export factor SUS1"
FT /id="PRO_0000367565"
SQ SEQUENCE 119 AA; 13770 MW; 35EEB1600FE8A8EA CRC64;
MSTNNSTQQQ DELDQIKSKI QDNLISSGNY DIINKQLKLQ LYESGWYDKV SQIASRELMD
HQQEVNSSNS NSSNSNKKNE LTFDQLFAFV KPKAEELVPN EVKQDILNRI TKYLDDIIQ
