SUS1_CRYNJ
ID SUS1_CRYNJ Reviewed; 100 AA.
AC P0CS72; Q55UI0; Q5KHW5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Transcription and mRNA export factor SUS1 {ECO:0000255|HAMAP-Rule:MF_03046};
GN Name=SUS1 {ECO:0000255|HAMAP-Rule:MF_03046}; OrderedLocusNames=CND05070;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC association with both the TREX-2 and the SAGA complexes. At the
CC promoters, SAGA is required for recruitment of the basal transcription
CC machinery. It influences RNA polymerase II transcriptional activity
CC through different activities such as TBP interaction and promoter
CC selectivity, interaction with transcription activators, and chromatin
CC modification through histone acetylation and deubiquitination. Within
CC the SAGA complex, participates in a subcomplex required for
CC deubiquitination of H2B and for the maintenance of steady-state H3
CC methylation levels. The TREX-2 complex functions in docking export-
CC competent ribonucleoprotein particles (mRNPs) to the nuclear entrance
CC of the nuclear pore complex (nuclear basket). TREX-2 participates in
CC mRNA export and accurate chromatin positioning in the nucleus by
CC tethering genes to the nuclear periphery. May also be involved in
CC cytoplasmic mRNA decay by interaction with components of P-bodies (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC complex (transcription and export complex 2), composed of at least
CC SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The
CC TREX-2 complex interacts with the nucleoporin NUP1. Component of the
CC 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5
CC distinct domains with specialized functions. Within the SAGA complex,
CC SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA
CC called the DUB module (deubiquitination module). Interacts directly
CC with THP1, SAC3, SGF11, and with the RNA polymerase II.
CC {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC Rule:MF_03046}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03046}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03046}.
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DR EMBL; AE017344; AAW42756.1; -; Genomic_DNA.
DR RefSeq; XP_570063.1; XM_570063.1.
DR AlphaFoldDB; P0CS72; -.
DR SMR; P0CS72; -.
DR PaxDb; P0CS72; -.
DR EnsemblFungi; AAW42756; AAW42756; CND05070.
DR GeneID; 3256896; -.
DR KEGG; cne:CND05070; -.
DR VEuPathDB; FungiDB:CND05070; -.
DR eggNOG; ENOG502SDC3; Eukaryota.
DR HOGENOM; CLU_134052_2_0_1; -.
DR InParanoid; P0CS72; -.
DR OMA; MIENGDW; -.
DR OrthoDB; 1538551at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0071819; C:DUBm complex; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0016578; P:histone deubiquitination; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; PTHR12514; 1.
DR Pfam; PF10163; EnY2; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; Cytoplasm; mRNA transport; Nucleus;
KW Protein transport; Reference proteome; Transcription;
KW Transcription regulation; Translocation; Transport.
FT CHAIN 1..100
FT /note="Transcription and mRNA export factor SUS1"
FT /id="PRO_0000367567"
SQ SEQUENCE 100 AA; 11357 MW; 4FD7A0F232C66E10 CRC64;
MSHVDVTVDE ATINAIRQRM LETGDWERIQ KLLRAHLEES GWVDDLKDLA KEKARAQDVP
NLENLVKQIS ESAAGMVSDN VKRDVMLEIE SVLDREVDQA
