ID   SUS1_KLULA              Reviewed;          96 AA.
AC   Q6CVU7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Transcription and mRNA export factor SUS1 {ECO:0000255|HAMAP-Rule:MF_03046};
GN   Name=SUS1 {ECO:0000255|HAMAP-Rule:MF_03046};
GN   OrderedLocusNames=KLLA0B09284g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC       association with both the TREX-2 and the SAGA complexes. At the
CC       promoters, SAGA is required for recruitment of the basal transcription
CC       machinery. It influences RNA polymerase II transcriptional activity
CC       through different activities such as TBP interaction and promoter
CC       selectivity, interaction with transcription activators, and chromatin
CC       modification through histone acetylation and deubiquitination. Within
CC       the SAGA complex, participates in a subcomplex required for
CC       deubiquitination of H2B and for the maintenance of steady-state H3
CC       methylation levels. The TREX-2 complex functions in docking export-
CC       competent ribonucleoprotein particles (mRNPs) to the nuclear entrance
CC       of the nuclear pore complex (nuclear basket). TREX-2 participates in
CC       mRNA export and accurate chromatin positioning in the nucleus by
CC       tethering genes to the nuclear periphery. May also be involved in
CC       cytoplasmic mRNA decay by interaction with components of P-bodies (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2
CC       complex (transcription and export complex 2), composed of at least
CC       SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The
CC       TREX-2 complex interacts with the nucleoporin NUP1. Component of the
CC       1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5
CC       distinct domains with specialized functions. Within the SAGA complex,
CC       SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA
CC       called the DUB module (deubiquitination module). Interacts directly
CC       with THP1, SAC3, SGF11, and with the RNA polymerase II.
CC       {ECO:0000255|HAMAP-Rule:MF_03046}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03046}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03046}.
CC   -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03046}.
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DR   EMBL; CR382122; CAH02335.1; -; Genomic_DNA.
DR   RefSeq; XP_451942.1; XM_451942.1.
DR   AlphaFoldDB; Q6CVU7; -.
DR   SMR; Q6CVU7; -.
DR   STRING; 28985.XP_451942.1; -.
DR   EnsemblFungi; CAH02335; CAH02335; KLLA0_B09284g.
DR   GeneID; 2897327; -.
DR   KEGG; kla:KLLA0_B09284g; -.
DR   eggNOG; ENOG502S9WJ; Eukaryota.
DR   HOGENOM; CLU_2360037_0_0_1; -.
DR   InParanoid; Q6CVU7; -.
DR   OMA; YESGWFD; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0000124; C:SAGA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:EnsemblFungi.
DR   GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:EnsemblFungi.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0016578; P:histone deubiquitination; IEA:UniProtKB-UniRule.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IEA:EnsemblFungi.
DR   GO; GO:0034729; P:histone H3-K79 methylation; IEA:EnsemblFungi.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IEA:EnsemblFungi.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.246.140; -; 1.
DR   HAMAP; MF_03046; ENY2_Sus1; 1.
DR   InterPro; IPR018783; TF_ENY2.
DR   InterPro; IPR038212; TF_EnY2_sf.
DR   Pfam; PF10163; EnY2; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Transcription;
KW   Transcription regulation; Translocation; Transport.
FT   CHAIN           1..96
FT                   /note="Transcription and mRNA export factor SUS1"
FT                   /id="PRO_0000367569"
SQ   SEQUENCE   96 AA;  11414 MW;  FD0D7BBACDC4B13E CRC64;
     MKYFNGLFSI FFFLLLTNYL NFNSRISNQL NQMLLDDGWI DKVKQLTREE MERSDSTNFV
     DILNKVEPQA LNMVNDKTRT EILQTIKEFL NDIVEV