SUSD3_HUMAN
ID SUSD3_HUMAN Reviewed; 255 AA.
AC Q96L08; Q49AA6; Q6UXV7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Sushi domain-containing protein 3;
GN Name=SUSD3; ORFNames=UNQ9387/PRO34275;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] THR-140.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [5]
RP SUBCELLULAR LOCATION, FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=24413080; DOI=10.1038/onc.2013.553;
RA Moy I., Todorovic V., Dubash A.D., Coon J.S., Parker J.B.,
RA Buranapramest M., Huang C.C., Zhao H., Green K.J., Bulun S.E.;
RT "Estrogen-dependent sushi domain containing 3 regulates cytoskeleton
RT organization and migration in breast cancer cells.";
RL Oncogene 34:323-333(2015).
CC -!- FUNCTION: May play a role in breast tumorigenesis by promoting
CC estrogen-dependent cell proliferation, cell-cell interactions and
CC migration. {ECO:0000269|PubMed:24413080}.
CC -!- INTERACTION:
CC Q96L08; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18194029, EBI-12109402;
CC Q96L08; P07306: ASGR1; NbExp=3; IntAct=EBI-18194029, EBI-1172335;
CC Q96L08; P27449: ATP6V0C; NbExp=3; IntAct=EBI-18194029, EBI-721179;
CC Q96L08; Q92843: BCL2L2; NbExp=3; IntAct=EBI-18194029, EBI-707714;
CC Q96L08; Q99675: CGRRF1; NbExp=3; IntAct=EBI-18194029, EBI-2130213;
CC Q96L08; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-18194029, EBI-12256978;
CC Q96L08; Q96B33: CLDN23; NbExp=3; IntAct=EBI-18194029, EBI-18201031;
CC Q96L08; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-18194029, EBI-11989440;
CC Q96L08; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-18194029, EBI-12208021;
CC Q96L08; Q07325: CXCL9; NbExp=3; IntAct=EBI-18194029, EBI-3911467;
CC Q96L08; P56851: EDDM3B; NbExp=3; IntAct=EBI-18194029, EBI-10215665;
CC Q96L08; Q9HCP6: HHATL; NbExp=3; IntAct=EBI-18194029, EBI-5916693;
CC Q96L08; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-18194029, EBI-12007212;
CC Q96L08; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-18194029, EBI-2804156;
CC Q96L08; P60201-2: PLP1; NbExp=3; IntAct=EBI-18194029, EBI-12188331;
CC Q96L08; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18194029, EBI-1052363;
CC Q96L08; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-18194029, EBI-8652744;
CC Q96L08; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-18194029, EBI-10226799;
CC Q96L08; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-18194029, EBI-8640191;
CC Q96L08; Q6PL24: TMED8; NbExp=3; IntAct=EBI-18194029, EBI-11603430;
CC Q96L08; P17152: TMEM11; NbExp=3; IntAct=EBI-18194029, EBI-723946;
CC Q96L08; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-18194029, EBI-348587;
CC Q96L08; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-18194029, EBI-10255122;
CC Q96L08; Q9BQJ4: TMEM47; NbExp=3; IntAct=EBI-18194029, EBI-13370320;
CC Q96L08; Q9Y2Y6: TMEM98; NbExp=3; IntAct=EBI-18194029, EBI-7333781;
CC Q96L08; Q9NRS4: TMPRSS4; NbExp=3; IntAct=EBI-18194029, EBI-10313040;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24413080};
CC Single-pass membrane protein {ECO:0000305}. Note=Prominently localized
CC to cell-cell borders. {ECO:0000269|PubMed:24413080}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96L08-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96L08-2; Sequence=VSP_020834;
CC Name=3;
CC IsoId=Q96L08-3; Sequence=VSP_020833;
CC -!- TISSUE SPECIFICITY: Highly expressed in estrogen receptor-positive
CC breast tumors. {ECO:0000269|PubMed:24413080}.
CC -!- INDUCTION: Up-regulated upon treatment with estradiol in MCF7 cells.
CC {ECO:0000269|PubMed:24413080}.
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DR EMBL; AY358190; AAQ88557.1; -; mRNA.
DR EMBL; AL451065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC014601; AAH14601.1; -; mRNA.
DR EMBL; BC041834; AAH41834.1; -; mRNA.
DR CCDS; CCDS6701.1; -. [Q96L08-1]
DR CCDS; CCDS69620.1; -. [Q96L08-2]
DR RefSeq; NP_001273934.1; NM_001287005.1. [Q96L08-2]
DR RefSeq; NP_001273935.1; NM_001287006.1.
DR RefSeq; NP_001273937.1; NM_001287008.1.
DR RefSeq; NP_659443.1; NM_145006.3. [Q96L08-1]
DR RefSeq; XP_011516660.1; XM_011518358.1. [Q96L08-2]
DR RefSeq; XP_011516661.1; XM_011518359.1. [Q96L08-2]
DR RefSeq; XP_011516663.1; XM_011518361.2. [Q96L08-2]
DR RefSeq; XP_016869939.1; XM_017014450.1. [Q96L08-2]
DR AlphaFoldDB; Q96L08; -.
DR SMR; Q96L08; -.
DR BioGRID; 128465; 51.
DR IntAct; Q96L08; 47.
DR STRING; 9606.ENSP00000364621; -.
DR GlyGen; Q96L08; 1 site.
DR iPTMnet; Q96L08; -.
DR PhosphoSitePlus; Q96L08; -.
DR SwissPalm; Q96L08; -.
DR BioMuta; SUSD3; -.
DR DMDM; 74751997; -.
DR EPD; Q96L08; -.
DR MassIVE; Q96L08; -.
DR PaxDb; Q96L08; -.
DR PeptideAtlas; Q96L08; -.
DR PRIDE; Q96L08; -.
DR ProteomicsDB; 77132; -. [Q96L08-1]
DR ProteomicsDB; 77133; -. [Q96L08-2]
DR ProteomicsDB; 77134; -. [Q96L08-3]
DR Antibodypedia; 28340; 46 antibodies from 17 providers.
DR DNASU; 203328; -.
DR Ensembl; ENST00000375469.5; ENSP00000364618.1; ENSG00000157303.11. [Q96L08-2]
DR Ensembl; ENST00000375472.8; ENSP00000364621.3; ENSG00000157303.11. [Q96L08-1]
DR GeneID; 203328; -.
DR KEGG; hsa:203328; -.
DR MANE-Select; ENST00000375472.8; ENSP00000364621.3; NM_145006.4; NP_659443.1.
DR UCSC; uc004atb.5; human. [Q96L08-1]
DR CTD; 203328; -.
DR DisGeNET; 203328; -.
DR GeneCards; SUSD3; -.
DR HGNC; HGNC:28391; SUSD3.
DR HPA; ENSG00000157303; Tissue enhanced (lymphoid tissue, testis).
DR MIM; 616429; gene.
DR neXtProt; NX_Q96L08; -.
DR OpenTargets; ENSG00000157303; -.
DR PharmGKB; PA128394766; -.
DR VEuPathDB; HostDB:ENSG00000157303; -.
DR eggNOG; ENOG502RY7E; Eukaryota.
DR GeneTree; ENSGT00390000006976; -.
DR HOGENOM; CLU_088608_0_0_1; -.
DR InParanoid; Q96L08; -.
DR OMA; QMWYQLR; -.
DR OrthoDB; 914714at2759; -.
DR PhylomeDB; Q96L08; -.
DR TreeFam; TF335828; -.
DR PathwayCommons; Q96L08; -.
DR SignaLink; Q96L08; -.
DR BioGRID-ORCS; 203328; 13 hits in 1075 CRISPR screens.
DR ChiTaRS; SUSD3; human.
DR GenomeRNAi; 203328; -.
DR Pharos; Q96L08; Tdark.
DR PRO; PR:Q96L08; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q96L08; protein.
DR Bgee; ENSG00000157303; Expressed in right testis and 107 other tissues.
DR ExpressionAtlas; Q96L08; baseline and differential.
DR Genevisible; Q96L08; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR CDD; cd00033; CCP; 1.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00084; Sushi; 1.
DR SMART; SM00032; CCP; 1.
DR SUPFAM; SSF57535; SSF57535; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Sushi; Transmembrane; Transmembrane helix.
FT CHAIN 1..255
FT /note="Sushi domain-containing protein 3"
FT /id="PRO_0000251973"
FT TOPO_DOM 1..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..93
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..75
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 61..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 1..118
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020833"
FT VAR_SEQ 1..30
FT /note="MRWAAATLRGKARPRGRAGVTTPAPGNRTG -> MKNIGLVMEWEIPEIIC
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_020834"
FT VARIANT 136
FT /note="K -> E (in dbSNP:rs1131773)"
FT /id="VAR_027744"
FT VARIANT 140
FT /note="S -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035663"
SQ SEQUENCE 255 AA; 27119 MW; C543191F3DE5DFE6 CRC64;
MRWAAATLRG KARPRGRAGV TTPAPGNRTG TCAKLRLPPQ ATFQVLRGNG ASVGTVLMFR
CPSNHQMVGS GLLTCTWKGS IAEWSSGSPV CKLVPPHETF GFKVAVIASI VSCAIILLMS
MAFLTCCLLK CVKKSKRRRS NRSAQLWSQL KDEDLETVQA AYLGLKHFNK PVSGPSQAHD
NHSFTTDHGE STSKLASVTR SVDKDPGIPR ALSLSGSSSS PQAQVMVHMA NPRQPLPASG
LATGMPQQPA AYALG
