SUSD3_MOUSE
ID SUSD3_MOUSE Reviewed; 269 AA.
AC Q9D176; Q80XL5; Q9CYV1; Q9DA86;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Sushi domain-containing protein 3;
GN Name=Susd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96L08};
CC Single-pass membrane protein {ECO:0000250|UniProtKB:Q96L08}.
CC Note=Prominently localized to cell-cell borders.
CC {ECO:0000250|UniProtKB:Q96L08}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D176-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D176-2; Sequence=VSP_020835;
CC Name=3;
CC IsoId=Q9D176-3; Sequence=VSP_020836, VSP_020837;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24394.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK003860; BAB23043.1; -; mRNA.
DR EMBL; AK006068; BAB24394.1; ALT_FRAME; mRNA.
DR EMBL; AK013276; BAB28764.1; -; mRNA.
DR EMBL; BC045525; AAH45525.1; -; mRNA.
DR CCDS; CCDS26498.1; -. [Q9D176-1]
DR CCDS; CCDS56880.1; -. [Q9D176-2]
DR RefSeq; NP_079767.2; NM_025491.3. [Q9D176-1]
DR RefSeq; NP_082616.1; NM_028340.1. [Q9D176-2]
DR AlphaFoldDB; Q9D176; -.
DR SMR; Q9D176; -.
DR STRING; 10090.ENSMUSP00000061423; -.
DR PhosphoSitePlus; Q9D176; -.
DR SwissPalm; Q9D176; -.
DR EPD; Q9D176; -.
DR PaxDb; Q9D176; -.
DR PRIDE; Q9D176; -.
DR ProteomicsDB; 254720; -. [Q9D176-1]
DR ProteomicsDB; 254721; -. [Q9D176-2]
DR Antibodypedia; 28340; 46 antibodies from 17 providers.
DR Ensembl; ENSMUST00000021816; ENSMUSP00000021816; ENSMUSG00000021384. [Q9D176-2]
DR Ensembl; ENSMUST00000058196; ENSMUSP00000061423; ENSMUSG00000021384. [Q9D176-1]
DR Ensembl; ENSMUST00000119721; ENSMUSP00000113631; ENSMUSG00000021384. [Q9D176-3]
DR GeneID; 66329; -.
DR KEGG; mmu:66329; -.
DR UCSC; uc007qiz.2; mouse. [Q9D176-1]
DR UCSC; uc007qja.2; mouse. [Q9D176-2]
DR UCSC; uc007qjb.1; mouse. [Q9D176-3]
DR CTD; 203328; -.
DR MGI; MGI:1913579; Susd3.
DR VEuPathDB; HostDB:ENSMUSG00000021384; -.
DR eggNOG; ENOG502RY7E; Eukaryota.
DR GeneTree; ENSGT00390000006976; -.
DR HOGENOM; CLU_088608_0_0_1; -.
DR InParanoid; Q9D176; -.
DR OMA; QMWYQLR; -.
DR OrthoDB; 914714at2759; -.
DR PhylomeDB; Q9D176; -.
DR TreeFam; TF335828; -.
DR BioGRID-ORCS; 66329; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q9D176; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D176; protein.
DR Bgee; ENSMUSG00000021384; Expressed in retinal neural layer and 88 other tissues.
DR ExpressionAtlas; Q9D176; baseline and differential.
DR Genevisible; Q9D176; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR CDD; cd00033; CCP; 1.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00084; Sushi; 1.
DR SMART; SM00032; CCP; 1.
DR SUPFAM; SSF57535; SSF57535; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Membrane;
KW Reference proteome; Sushi; Transmembrane; Transmembrane helix.
FT CHAIN 1..269
FT /note="Sushi domain-containing protein 3"
FT /id="PRO_0000251974"
FT TOPO_DOM 1..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..93
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..75
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 61..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 1..29
FT /note="MRRTSATLRGRARPRWRAGNTTPVPVNQT -> MRRLSLSKVTCLALESK
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020835"
FT VAR_SEQ 143..170
FT /note="TAQLWYQLRGEDLETVQAAYLGLKGHNH -> YSGLMSFQKLCLAVRLLITS
FT CQVPWGSV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020836"
FT VAR_SEQ 171..269
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020837"
SQ SEQUENCE 269 AA; 28285 MW; 1322EB3F7B922949 CRC64;
MRRTSATLRG RARPRWRAGN TTPVPVNQTG TCAQLHPPPQ GTLQVVRGDG TSLGTVLIFH
CPSGHQMVGS GLLTCAWNGS TVDWSSGSPV CKAVPPHETF GFKVAVIASI VSCAIILLMS
MAFLTCCLLK CVQKNERRRA DRTAQLWYQL RGEDLETVQA AYLGLKGHNH NNSSSVGGGN
GGPSGGGGKP GIQHSQAHDN HSFTTDPGDI REQAGVTHSV DKDPWTFRMG TPGPGGCSSS
PGTYVMVHAL NSAGLAPGNP GRPKVYLPG
