SUSD5_HUMAN
ID SUSD5_HUMAN Reviewed; 629 AA.
AC O60279;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Sushi domain-containing protein 5;
DE Flags: Precursor;
GN Name=SUSD5; Synonyms=KIAA0527;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-40 AND ASP-378.
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA25453.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB011099; BAA25453.1; ALT_INIT; mRNA.
DR EMBL; AC123900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46787.1; -.
DR PIR; T00073; T00073.
DR RefSeq; NP_056366.1; NM_015551.1.
DR AlphaFoldDB; O60279; -.
DR BioGRID; 117498; 19.
DR IntAct; O60279; 11.
DR MINT; O60279; -.
DR STRING; 9606.ENSP00000308727; -.
DR GlyGen; O60279; 9 sites, 3 O-linked glycans (8 sites).
DR iPTMnet; O60279; -.
DR PhosphoSitePlus; O60279; -.
DR SwissPalm; O60279; -.
DR BioMuta; SUSD5; -.
DR EPD; O60279; -.
DR jPOST; O60279; -.
DR MassIVE; O60279; -.
DR MaxQB; O60279; -.
DR PaxDb; O60279; -.
DR PeptideAtlas; O60279; -.
DR PRIDE; O60279; -.
DR ProteomicsDB; 49308; -.
DR Antibodypedia; 27889; 93 antibodies from 20 providers.
DR DNASU; 26032; -.
DR Ensembl; ENST00000309558.8; ENSP00000308727.3; ENSG00000173705.9.
DR GeneID; 26032; -.
DR KEGG; hsa:26032; -.
DR MANE-Select; ENST00000309558.8; ENSP00000308727.3; NM_015551.2; NP_056366.1.
DR UCSC; uc003cfo.2; human.
DR CTD; 26032; -.
DR DisGeNET; 26032; -.
DR GeneCards; SUSD5; -.
DR HGNC; HGNC:29061; SUSD5.
DR HPA; ENSG00000173705; Low tissue specificity.
DR neXtProt; NX_O60279; -.
DR OpenTargets; ENSG00000173705; -.
DR PharmGKB; PA143485627; -.
DR VEuPathDB; HostDB:ENSG00000173705; -.
DR eggNOG; ENOG502QQ3P; Eukaryota.
DR GeneTree; ENSGT00390000009163; -.
DR HOGENOM; CLU_017358_0_0_1; -.
DR InParanoid; O60279; -.
DR OMA; EPCVGDE; -.
DR OrthoDB; 393645at2759; -.
DR PhylomeDB; O60279; -.
DR TreeFam; TF336259; -.
DR PathwayCommons; O60279; -.
DR SignaLink; O60279; -.
DR BioGRID-ORCS; 26032; 7 hits in 1065 CRISPR screens.
DR GenomeRNAi; 26032; -.
DR Pharos; O60279; Tdark.
DR PRO; PR:O60279; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O60279; protein.
DR Bgee; ENSG00000173705; Expressed in descending thoracic aorta and 152 other tissues.
DR ExpressionAtlas; O60279; baseline and differential.
DR Genevisible; O60279; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IBA:GO_Central.
DR CDD; cd00033; CCP; 1.
DR CDD; cd03521; Link_domain_KIAA0527_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000538; Link_dom.
DR InterPro; IPR042059; SUSD5_Link_domain.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00193; Xlink; 1.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR SUPFAM; SSF57535; SSF57535; 1.
DR PROSITE; PS50963; LINK_2; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Membrane; Reference proteome; Signal; Sushi; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..629
FT /note="Sushi domain-containing protein 5"
FT /id="PRO_0000274247"
FT TOPO_DOM 36..574
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 596..629
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 39..134
FT /note="Link"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323"
FT DOMAIN 138..199
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 225..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 61..132
FT /evidence="ECO:0000250"
FT DISULFID 140..184
FT /evidence="ECO:0000250"
FT DISULFID 167..197
FT /evidence="ECO:0000250"
FT VARIANT 40
FT /note="F -> L (in dbSNP:rs9637517)"
FT /evidence="ECO:0000269|PubMed:9628581"
FT /id="VAR_051391"
FT VARIANT 52
FT /note="L -> F (in dbSNP:rs9637517)"
FT /id="VAR_030217"
FT VARIANT 216
FT /note="R -> K (in dbSNP:rs9872477)"
FT /id="VAR_051392"
FT VARIANT 228
FT /note="R -> K (in dbSNP:rs9872477)"
FT /id="VAR_030218"
FT VARIANT 378
FT /note="E -> D (in dbSNP:rs6810039)"
FT /evidence="ECO:0000269|PubMed:9628581"
FT /id="VAR_051393"
FT CONFLICT 272
FT /note="L -> S (in Ref. 1; BAA25453)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 629 AA; 68021 MW; 51CB3C12D932FD9E CRC64;
MTAEGPSPPA RWHRRLPGLW AAALLLLGLP RLSVRADGKF FVLESQNGSQ GLQLEAARLS
CKSRGAHLAS ADELRRVVQD CSFAVCTTGW LADGTLGTTV CSKGSGEQQI MRAVDVRIES
NPVPGGTYSA LCIKDEEKPC GDPPSFPHTI LQGRTGLEMG DELLYVCAPG HIMGHRETAF
TLLCNSCGEW YGLVQACGKD EAEAHIDYED NFPDDRSVSF RELMEDSRTE ADEDRGQGDS
SEEAPKQDRL VSISVGRENI ARDKVFVPTT GLPGAGSSVP ADSPGSRLLQ KHLFWFPAEA
FHKPGLEKEV DDDTKKQFSA GDNHSGVKLV PGEPETKVIY GNTDGPSGPF VGKNDSKAGD
PVVSSSDESW LDGYPVTEGA WRKTEAEEEE DGDRGDGSVG LDENVLVTPD QPILVEVKKP
KSSTLTPSEG MTHSSVLPSQ MLDVEALALR PVNASETEGI GDGDLTKYQS TLPWRFITEE
SPMATLSYEL TSSTLEILTV NTVKQTPNHI PSTIMATTQP PVETTVPEIQ DSFPYLLSED
FFGQEGPGPG ASEELHPTLE SCVGDGCPGL SRGPVIATIV TVLCLLLLLA GVGMVWGYRK
CQHKSSVYKL NVGQRQARHY HQQIEMEKV
