SUSD6_MOUSE
ID SUSD6_MOUSE Reviewed; 302 AA.
AC Q8BGE4;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Sushi domain-containing protein 6 {ECO:0000250|UniProtKB:Q92537, ECO:0000312|MGI:MGI:2444661};
DE AltName: Full=Drago;
DE Flags: Precursor;
GN Name=Susd6 {ECO:0000250|UniProtKB:Q92537, ECO:0000312|MGI:MGI:2444661};
GN Synonyms=Kiaa0247 {ECO:0000312|MGI:MGI:2444661};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAH40401.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC35691.1};
RC TISSUE=Oviduct {ECO:0000312|EMBL:BAC35691.1}, and
RC Skin {ECO:0000312|EMBL:BAE36207.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Ensembl:ENSMUSP00000064961,
RC ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH40401.1};
RC TISSUE=Salivary gland {ECO:0000312|EMBL:AAH40401.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24652652; DOI=10.1093/jnci/dju053;
RA Polato F., Rusconi P., Zangrossi S., Morelli F., Boeri M., Musi A.,
RA Marchini S., Castiglioni V., Scanziani E., Torri V., Broggini M.;
RT "DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that
RT cooperates with p53 as oncosuppressor. [Corrected].";
RL J. Natl. Cancer Inst. 106:1-10(2014).
CC -!- FUNCTION: May play a role in growth-suppressive activity and cell
CC death. May be involved in the production of chemokine molecules in
CC umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte
CC LPS-induced medium (By similarity). Plays a role in preventing tumor
CC onset (PubMed:24652652). {ECO:0000250|UniProtKB:Q92537,
CC ECO:0000269|PubMed:24652652}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice are viable and fertile and do not show any
CC notable developmental defect or spontaneous tumor development within 2
CC years. SUSD6 and TP53 double knockout mice show an increase in tumor
CC development and a decrease in lifespan compared to TP53 knockout mice
CC carrying wild-type SUSD6 (PubMed:24652652).
CC {ECO:0000269|PubMed:24652652}.
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DR EMBL; AK054203; BAC35691.1; -; mRNA.
DR EMBL; AK161132; BAE36207.1; -; mRNA.
DR EMBL; AC127337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466590; EDL02681.1; -; Genomic_DNA.
DR EMBL; BC040401; AAH40401.1; -; mRNA.
DR CCDS; CCDS26016.1; -.
DR RefSeq; NP_001229348.1; NM_001242419.1.
DR RefSeq; NP_848797.1; NM_178682.4.
DR AlphaFoldDB; Q8BGE4; -.
DR SMR; Q8BGE4; -.
DR STRING; 10090.ENSMUSP00000064961; -.
DR MaxQB; Q8BGE4; -.
DR PaxDb; Q8BGE4; -.
DR PRIDE; Q8BGE4; -.
DR ProteomicsDB; 254610; -.
DR Antibodypedia; 25061; 77 antibodies from 19 providers.
DR DNASU; 217684; -.
DR Ensembl; ENSMUST00000068519; ENSMUSP00000064961; ENSMUSG00000021133.
DR GeneID; 217684; -.
DR KEGG; mmu:217684; -.
DR UCSC; uc007obi.2; mouse.
DR CTD; 9766; -.
DR MGI; MGI:2444661; Susd6.
DR VEuPathDB; HostDB:ENSMUSG00000021133; -.
DR eggNOG; ENOG502QYTF; Eukaryota.
DR GeneTree; ENSGT00940000157120; -.
DR HOGENOM; CLU_044351_0_1_1; -.
DR InParanoid; Q8BGE4; -.
DR OMA; NGGYVCH; -.
DR OrthoDB; 1224817at2759; -.
DR PhylomeDB; Q8BGE4; -.
DR TreeFam; TF332459; -.
DR BioGRID-ORCS; 217684; 11 hits in 73 CRISPR screens.
DR ChiTaRS; Susd6; mouse.
DR PRO; PR:Q8BGE4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BGE4; protein.
DR Bgee; ENSMUSG00000021133; Expressed in stroma of bone marrow and 244 other tissues.
DR ExpressionAtlas; Q8BGE4; baseline and differential.
DR Genevisible; Q8BGE4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008219; P:cell death; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR CDD; cd00033; CCP; 1.
DR InterPro; IPR042866; SUSD6.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46839; PTHR46839; 1.
DR Pfam; PF00084; Sushi; 1.
DR SMART; SM00032; CCP; 1.
DR SUPFAM; SSF57535; SSF57535; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Membrane; Reference proteome; Signal; Sushi; Transmembrane;
KW Transmembrane helix; Tumor suppressor.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..302
FT /note="Sushi domain-containing protein 6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000432223"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 40..104
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 202..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 42..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 74..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 302 AA; 31978 MW; A2360FDC71B69F23 CRC64;
MCHGKIAPKS SSEFVVTSVG HGVFLQLVIL CALLGDGLAS VCPLPPEPEN GGYICHPRPC
KDPLTAGSVI EYLCAEGYML KGDYKYLTCK NGEWTPAMEV SCHLIEDKET HALGVPALSI
VASTASSVAL ILLLVVLFVL LQPKLKSFHH SRREQGVSGD QVSIMVDGVQ VALPSYEEAV
YGSSGHCMPP ADPRVQIVLS EGSAPSGRNM PREQQLQGQE ACSSAGGEDE APGHSGLCEA
WGSQGSETVM VHQATTSSWV AGSGSSRPTH KDTADSENSD IQSLLSLTSE EYTDDIPLLK
EA
