SUSD_BACO1
ID SUSD_BACO1 Reviewed; 546 AA.
AC A7LXT5;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=SusD-like protein BACOVA_02651;
DE Flags: Precursor;
GN ORFNames=BACOVA_02651;
OS Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 /
OS CCUG 4943 / NCTC 11153).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=411476;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC
RC 11153;
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Bacteroides ovatus (ATCC 8483).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND PATHWAY.
RX PubMed=24463512; DOI=10.1038/nature12907;
RA Larsbrink J., Rogers T.E., Hemsworth G.R., McKee L.S., Tauzin A.S.,
RA Spadiut O., Klinter S., Pudlo N.A., Urs K., Koropatkin N.M., Creagh A.L.,
RA Haynes C.A., Kelly A.G., Cederholm S.N., Davies G.J., Martens E.C.,
RA Brumer H.;
RT "A discrete genetic locus confers xyloglucan metabolism in select human gut
RT Bacteroidetes.";
RL Nature 506:498-502(2014).
CC -!- FUNCTION: Polysaccharide-binding protein present at the surface of the
CC cell. Probably mediates xyloglucan-binding before xyloglucan transport
CC in the periplasm for degradation. {ECO:0000269|PubMed:24463512}.
CC -!- PATHWAY: Glucan metabolism; xyloglucan degradation.
CC {ECO:0000269|PubMed:24463512}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}. Note=Cell outer membrane localization is predicted by
CC analogy with the archetypal sus locus. {ECO:0000269|PubMed:24463512}.
CC -!- MISCELLANEOUS: Gut bacteria supply the human body with energy from
CC dietary polysaccharides through glycosidases that are absent in the
CC human genome. Xyloglucans are a ubiquitous family of highly branched
CC plant cell wall polysaccharides present in the vegetables we consume.
CC Enzymes involved in xyloglucan degradation mediate the conversion of
CC otherwise indigestible plant polysaccharides to short-chain fatty acids
CC (PubMed:24463512). {ECO:0000305|PubMed:24463512}.
CC -!- SIMILARITY: Belongs to the SusD family. {ECO:0000305}.
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DR EMBL; AAXF02000049; EDO11442.1; -; Genomic_DNA.
DR PDB; 5E75; X-ray; 1.36 A; A=28-546.
DR PDB; 5E76; X-ray; 2.30 A; A=36-546.
DR PDBsum; 5E75; -.
DR PDBsum; 5E76; -.
DR AlphaFoldDB; A7LXT5; -.
DR SMR; A7LXT5; -.
DR STRING; 411476.BACOVA_02651; -.
DR EnsemblBacteria; EDO11442; EDO11442; BACOVA_02651.
DR eggNOG; COG0561; Bacteria.
DR HOGENOM; CLU_015553_1_3_10; -.
DR UniPathway; UPA01045; -.
DR Proteomes; UP000005475; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030247; F:polysaccharide binding; IDA:UniProtKB.
DR GO; GO:0085030; P:symbiotic process benefiting host; IDA:UniProtKB.
DR GO; GO:2000899; P:xyloglucan catabolic process; IDA:UniProtKB.
DR InterPro; IPR033985; SusD-like_N.
DR InterPro; IPR012944; SusD_RagB_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF14322; SusD-like_3; 1.
DR Pfam; PF07980; SusD_RagB; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Cell outer membrane; Lipoprotein;
KW Membrane; Palmitate; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 22..546
FT /note="SusD-like protein BACOVA_02651"
FT /id="PRO_0000425884"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT HELIX 44..51
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 52..55
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 57..59
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 60..63
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 67..71
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 72..76
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 81..84
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 85..89
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 97..122
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 130..152
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 155..158
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 164..169
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 178..195
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 207..222
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 223..225
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 232..248
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 257..261
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 263..265
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 271..275
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 283..285
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 290..293
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 300..302
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 313..318
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 324..330
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 343..345
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 352..354
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 365..368
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 382..386
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 387..399
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 409..420
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 427..429
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 431..442
FT /evidence="ECO:0007829|PDB:5E75"
FT TURN 443..446
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 448..458
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 460..468
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 477..481
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 487..492
FT /evidence="ECO:0007829|PDB:5E75"
FT STRAND 496..502
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 503..505
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 517..519
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 526..531
FT /evidence="ECO:0007829|PDB:5E75"
FT HELIX 533..536
FT /evidence="ECO:0007829|PDB:5E75"
SQ SEQUENCE 546 AA; 62096 MW; 8C3CF6641D560CDD CRC64;
MRIFMKSKLL VIATTALLFA ACSDSFLDRA PEGNYVDATF YTSDEALEAA TAPLYNRAWF
DYNQRSIVPI GSGRANDMYS PWNYPQFVTF QVTALDENLS GAWSGFYSVV TMANSVINAV
ETQTQGSVSE AAKTKAIAEA RLMRACAYFY MLRIWGPVIL IEDNQKLVDN PVRPLNREED
VFQFIINDLN YAVDNLSEQS DKGRATSWAA KGILAKVYLA RSGWNNGGTR DEGDLELARQ
YASDVCENSG LDLMTNYEDL FKYKNNNNQE SLLAMQWVPL GEWYECNTLL SDLAFSTEVT
GGVNCWSSYN GSIDMLQQYE LADTLRRNAT FFTKGSYYSY ICIKDGGYTY KGTASPIKKG
VPGGPDDDND GKVKQMNSPL NTYILRLADV YLTYAEACLG NNSTLSDGRG LYFFNRVRER
AKINKKSSIT LDDIIRERRV EFGMEYSNWY DMVTWFRYLP DKMLNYFNNQ WRGYRTDAII
KDEDGKLHFG KYDTDGTTFL EGPEYYTAPE FTINIEAEDI FLPYPESDVI QNPLLNEPPV
PYTFNE
